WormBase Tree Display for Gene: WBGene00001878

WBGene00001878 SMap: S_parent: Sequence: T10C6
  Identity: Version: 1
    Name: CGC_name: his-4 Person_evidence: WBPerson160
      Sequence_name: T10C6.11
      Molecular_name: T10C6.11
        T10C6.11.1
        CE10538
      Other_name: CELE_T10C6.11 Accession_evidence: NDB BX284605
      Public_name: his-4
    DB_info: Database: AceView gene 5Q520
        WormQTL gene WBGene00001878
        WormFlux gene WBGene00001878
        NDB locus_tag CELE_T10C6.11
        Panther gene CAEEL|WormBase=WBGene00001878|UniProtKB=Q27894
          family PTHR23428
        NCBI gene 180072
        RefSeq protein NM_074630.5
        SwissProt UniProtAcc Q27894
        UniProt_GCRP UniProtAcc Q27894
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: his
    Allele (19)
    Legacy_information: [C.elegansII] NMK. Histone type H2B, HIS1 cluster. [Roberts et al. 1989; EM]
    In_cluster: HIS1_cluster
    RNASeq_FPKM (74)
    GO_annotation (12)
    Ortholog (161)
    Paralog (16)
    Structured_description: Concise_description: his-4 encodes an H2B histone. Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable DNA binding activity. Predicted to be located in chromosome and nucleus. Predicted to be part of nucleosome. Is an ortholog of several human genes including H2BC3 (H2B clustered histone 3); H2BC5 (H2B clustered histone 5); and H2BC8 (H2B clustered histone 8). Paper_evidence: WBPaper00065943
            WBPaper00067038
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS296 version of WormBase
          Date_last_updated: 20 Mar 2025 00:00:00
  Molecular_info: Corresponding_CDS: T10C6.11
    Corresponding_CDS_history: T10C6.11:wp229
    Corresponding_transcript: T10C6.11.1
    Other_sequence: EY459661.1
      DAC01755_1
      DA01284
      RSC01664_1
      Name_isotig04738
      TVC01350_1
      DA01283
      ACC06568_1
      TV00274
      RS10407
    Associated_feature: WBsf653469
      WBsf653470
      WBsf669785
      WBsf669786
      WBsf669787
      WBsf982062
      WBsf235107
  Experimental_info: RNAi_result (32)
    Expr_pattern: Chronogram37
      Expr6658
      Expr1031106
      Expr1156625
      Expr2012463
      Expr2030701
    Drives_construct: WBCnstr00003705
      WBCnstr00036633
    Construct_product: WBCnstr00021175
      WBCnstr00036633
    Microarray_results (13)
    Expression_cluster: WBPaper00029359_1280
      WBPaper00029359_1444
      WBPaper00029359_1504
      WBPaper00029359_1578
      WBPaper00029359_1604
      WBPaper00031132:LiCl_upregulated
      WBPaper00038289:oocyte_protein
      WBPaper00038438:D.coniospora_12hr_upregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_downregulated_RNAseq
      WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
      WBPaper00040965:lipid-droplet_associated_protein
      WBPaper00044316:CH3HgCl_7.5uM_downregulated
      WBPaper00044736:oscillating_dev_expression
      WBPaper00044746:aging_upregulated_Day5
      WBPaper00044746:aging_upregulated_HeatShock
      WBPaper00045774:clk-1_upregulated
      WBPaper00046303:P.aeruginosa_downregulated_protein
      WBPaper00046795:starvation_upregulated
      WBPaper00046887:WNT-target
      WBPaper00048810:CoQ-deficiency_upregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048971:daf-16(mgDf50)_downregulated_L1
      WBPaper00048988:neuron_expressed
      WBPaper00049377:MWCNT_upregulated
      WBPaper00049626:UNC-75_target
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050370:dpy-21(e428)_L3_downregulated
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053388:dauer_regulated_Cluster6
      WBPaper00053402:cco-1(RNAi)_downregulated
      WBPaper00053664:ins-11(tm1053)_upregulated
      WBPaper00054410:set-26(tm2467)_upregulated
      WBPaper00055013:HMG-4_interacting_protein
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055482:Tunicamycin_upregulated
      WBPaper00056039:efa-6(tm3124)_downregulated
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056809:smn-1(ok355)_upregulated
      WBPaper00056826:SGP_biased
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057068:Cadmium_downregulated
      WBPaper00057068:ints-4(RNAi)_upregulated_Cadmium
      WBPaper00057140:meg-3(tm4259)_meg-4(ax2026)_upregulated
      WBPaper00057140:pptr-1(tm3103)_upregulated
      WBPaper00057288:Cold_downregulated_protein
      WBPaper00058691:sin-3(tm1276)_downregulated
      WBPaper00058958:100mGy-irradiation-72h_upregulated
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059440:GLP-1_represseded
      WBPaper00059440:LAG-1_repressed_48hr-auxin
      WBPaper00059471:EGL-43_interacting
      WBPaper00059739:hira-1(gk835598)_upregulated_adult
      WBPaper00059739:hira-1(gk835598)_upregulated_L1
      WBPaper00060014:set-2(tm1630)_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060908:TEBP-1_interacting
      WBPaper00060908:TEBP-2_interacting
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00060909:atfs-1(et18)_upregulated
      WBPaper00061340:Arcade_cell_anterior_and_posterior
      WBPaper00061340:DVC_parent
      WBPaper00061340:M1_parent
      WBPaper00061340:RIA_parent
      WBPaper00061377:MYRF-1_interacting
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061479:mep-1(ne4629)_upregulated
      WBPaper00061527:his-20_965-his-4
      WBPaper00061530:nhr-49(e2144)_upregulated
      WBPaper00061613:human-alpha-Synuclein(A53T)_upregulated
      WBPaper00061613:human-amyloid-beta_alpha-Synuclein(A53T)_upregulated
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00062056:dpl-1(n2994)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00062585:hlh-26(ok1453)_downregulated_E.faecium
      WBPaper00062672:dcp-66(RNAi)_upregulated
      WBPaper00062672:let-418(n3536)dcp-66(RNAi)_upregulated
      WBPaper00062672:let-418(n3536)_upregulated
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064201:SNA-1_interacting
      WBPaper00064201:SNA-3_interacting
      WBPaper00064509:static-magnetic-field_upregulated
      WBPaper00065086:JU1400_N.ausubeli_regulated
      WBPaper00065086:N2_N.ausubeli_regulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065149:lin-52(n771)_upregulated
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065746:tmc-1(rg1003)_downregulated
      WBPaper00065841:30_2
      WBPaper00065926:pgph-2(overepxreesion)_upregulated
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065984:pals-17(syb3980)_downregulated
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066204:CdCl2_downregulated_mRNA
      WBPaper00066410:mbl-1(syb4345)_upregulated
      WBPaper00066410:mbl-1(tm1563)_upregulated
      WBPaper00066618:fmi-1(rh308)_downregulated
      WBPaper00066703:L.plantarum-pdxH_downregulated
      WBPaper00066831:male-neuron_aging_upregulated
      WBPaper00067044:lin-53(RNAi)_upregulated
      WBPaper00067079:adr-1(tm668);adr-2(ok735)_upregulated_L4
      WBPaper00067147:germline_expressed
      WBPaper00067259:starvation_upregulated_intestine
      WBPaper00067323:Trametinib_downregulated
      WBPaper00067493:gonad-cyd-1(RNAi)_downregulated_daf-2(e1370)
      WBPaper00067518:food_downregulated_N2
      WBPaper00067518:food_downregulated_raga-1(ok386)
      cgc4489_group_13
      WBPaper00025032:cluster_69
      WBPaper00025099:MA_specific
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00027342:alpha-Synuclein(A53T)_downregulated
      WBPaper00027342:alpha-Synuclein(WT)_downregulated
      WBPaper00030985:Serratia_marcesens_downregulated
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00032165:differentially_expressed_with_age_medoid_7
      WBPaper00032948:FedUp
      WBPaper00034739:N2lessDR1350
      WBPaper00036286:Pattern_E
      WBPaper00036375:depleted_in_PVD_OLL
      WBPaper00036383:ash-2_L3_regulated
      WBPaper00038060:SUMO-1_downregulated
      WBPaper00038172:tax-6null_down_regulated
      WBPaper00038304:octr-1_regulated
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_juvenile
      WBPaper00040985:AIN-2_asynchronous_intestine
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00045263:isp-1(qm150)_downregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00046548:dafachronic-acid_upregulated
      WBPaper00048637:lin-35(n745)_starvation_downregulated
      WBPaper00050538:Fasting_upregulated
      [cgc6390]:Cluster_B
    Interaction (209)
  Map_info: Map: V Position: 9.37822
    Positive: Positive_clone: T10C6 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00001150
    WBPaper00005142
    WBPaper00038491
    WBPaper00055090
  Remark: is NOT an H4 gene
    T10C6.b appears to have become T10C6.11 [sdm 000920]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene