WormBase Tree Display for Gene: WBGene00006745
expand all nodes | collapse all nodes | view schema
WBGene00006745 | SMap | S_parent | Sequence | B0273 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | unc-5 | Person_evidence | WBPerson261 | |||||
Sequence_name | B0273.4 | ||||||||
Molecular_name (19) | |||||||||
Other_name | CELE_B0273.4 | Accession_evidence | NDB | BX284604 | |||||
Public_name | unc-5 | ||||||||
DB_info | Database | AceView | gene | 4G260 | |||||
WormQTL | gene | WBGene00006745 | |||||||
WormFlux | gene | WBGene00006745 | |||||||
NDB | locus_tag | CELE_B0273.4 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00006745|UniProtKB=Q26261 | |||||||
family | PTHR12582 | ||||||||
NCBI | gene | 177334 | |||||||
RefSeq | protein | NM_001392311.1 | |||||||
NM_068422.6 | |||||||||
NM_001306822.3 | |||||||||
NM_068421.6 | |||||||||
NM_001306820.3 | |||||||||
NM_001380233.1 | |||||||||
SwissProt | UniProtAcc | Q26261 | |||||||
TREEFAM | TREEFAM_ID | TF316767 | |||||||
UniProt_GCRP | UniProtAcc | Q26261 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | unc | ||||||||
Reference_allele | WBVar00142936 | ||||||||
Allele (350) | |||||||||
Legacy_information | e53 : severe coiler grows well; L1 also severe coiler; dorsal hypodermal cells abnormal dorsal nerve cord absent or almost absent cord commissures fail to reach targets muscle arms misdirected; distribution of cell bodies in ventral cord is disorganized; Egl-c. ES3 ME0. NA7 (e553 (resemble e53) e152 (weaker phenotype behaviorally and anatomically dorsal cord partially formed) etc.). | ||||||||
See also e2349, e2355, e2387 | |||||||||
[C.elegansII] e53 : severe coiler, grows well; L1 also severe coiler; dorsal hypodermal cells abnormal, dorsal nerve cord absent or almost absent, cord commissures fail to reach targets; muscle arms misdirected; distribution of cell bodies in ventral cord is disorganized; abnormal gonad arms;Egl-c. ES3 ME0. OA>10: e553 (resembles e53), e152 (weaker phenotype behaviorally and anatomically, dorsal cord partially formed), bx8, ev447,st1001tci, etc. See also unc-6, unc-40. Cloned: 3.0 and 3.1 kb transcripts (different 5') ,encode predicted 919 aa transmembrane protein,2 Ig domains and 2 TSP domains. Mosaic analysis indicates autonomous action in neurons, DTC; ectopic expression in touch cells can cause their dorsalward migration. [Hedgecock et al. 1990; Leung-Hagesteijn et al. 1992; Hamelin et al. 1993; NW] | |||||||||
Strain (67) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (52) | |||||||||
Ortholog (52) | |||||||||
Structured_description | Concise_description | unc-5 encodes a netrin receptor; unc-5 activity is required cell autonomously for dorsalward cell and pioneer motor axon migrations along the body wall that are essential for normal locomotion and gonad development; unc-5 mRNAs are expressed throughout the entire life cycle, with increasing levels seen as animals progess to adulthood. | Paper_evidence | WBPaper00001619 | |||||
WBPaper00005582 | |||||||||
Curator_confirmed | WBPerson567 | ||||||||
WBPerson1843 | |||||||||
Date_last_updated | 25 Jan 2006 00:00:00 | ||||||||
Automated_description | Enables netrin receptor activity and protein tyrosine kinase binding activity. Involved in several processes, including axon guidance; regulation of neuron projection development; and sex differentiation. Acts upstream of or within distal tip cell migration. Located in axonal growth cone. Expressed in several structures, including distal tip cell; excretory canal; head neurons; motor neurons; and somatic nervous system. Is an ortholog of human UNC5A (unc-5 netrin receptor A); UNC5B (unc-5 netrin receptor B); and UNC5C (unc-5 netrin receptor C). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||||
Date_last_updated | 24 Apr 2024 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | B0273.4a | |||||||
B0273.4b | |||||||||
B0273.4c | |||||||||
B0273.4d | |||||||||
B0273.4e | |||||||||
B0273.4f | |||||||||
Corresponding_CDS_history | B0273.4b:wp134 | ||||||||
Corresponding_transcript | B0273.4a.1 | ||||||||
B0273.4b.1 | |||||||||
B0273.4c.1 | |||||||||
B0273.4d.1 | |||||||||
B0273.4d.2 | |||||||||
B0273.4e.1 | |||||||||
B0273.4f.1 | |||||||||
Other_sequence | JI475712.1 | ||||||||
JI459463.1 | |||||||||
CR01727 | |||||||||
CRC00510_2 | |||||||||
CRC06468_1 | |||||||||
CR03346 | |||||||||
CJC11776_1 | |||||||||
JI165198.1 | |||||||||
Dviv_isotig23366 | |||||||||
Associated_feature (24) | |||||||||
Experimental_info | RNAi_result (14) | ||||||||
Expr_pattern (11) | |||||||||
Drives_construct | WBCnstr00000353 | ||||||||
WBCnstr00000457 | |||||||||
WBCnstr00000460 | |||||||||
WBCnstr00000461 | |||||||||
WBCnstr00000462 | |||||||||
WBCnstr00000475 | |||||||||
WBCnstr00000478 | |||||||||
WBCnstr00000869 | |||||||||
WBCnstr00001306 | |||||||||
WBCnstr00003413 | |||||||||
WBCnstr00010750 | |||||||||
WBCnstr00013826 | |||||||||
WBCnstr00014477 | |||||||||
WBCnstr00017204 | |||||||||
WBCnstr00019671 | |||||||||
WBCnstr00022893 | |||||||||
WBCnstr00034178 | |||||||||
Construct_product (13) | |||||||||
Microarray_results (30) | |||||||||
Expression_cluster (158) | |||||||||
Interaction (205) | |||||||||
WBProcess | WBbiopr:00000025 | ||||||||
Map_info | Map | IV | Position | 1.78303 | Error | 0.002438 | |||
Well_ordered | |||||||||
Positive | Positive_clone | B0273 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
C37G6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
Negative | Outside_rearr | nDp5 | |||||||
Mapping_data | 2_point (21) | ||||||||
Multi_point (96) | |||||||||
Pos_neg_data | 3700 | ||||||||
9031 | |||||||||
9036 | |||||||||
10892 | |||||||||
Landmark_gene | |||||||||
Reference (347) | |||||||||
Remark | [Culotti J] The unc-5 expression pattern is now published in Su et al., Development 127,585-594 (2000) | ||||||||
Method | Gene |