e151 : weak coiler tends to coil tail active; very disorganized ventral nerve cord; mutant focus in ABp descendants; ES3 ME1. Similar phenotype in e151/Df. NA4 (e54 (weaker allele) e95 etc.).
[C.elegansII] e151 : weak coiler tends to coil, tail active, good head movement; very disorganized ventral nerve cord; mosaic analysis indicates mutant focus in ventral cord motor neurons. Similar phenotype ine151/Df. ES3 ME1.OA>5: e54 (weaker allele), e95, mn419, p1001 etc. Cloned: polymorphisms identified in mn419 and derivatives (cosmid F42D1). [Brenner 1974; Herman and Kari 1987; NG; SP]
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; histone acetyltransferase binding activity; and identical protein binding activity. Involved in several processes, including dauer larval development; neuron differentiation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in ABalappaap; ABalappaapp; and neurons. Human ortholog(s) of this gene implicated in hypotonia, ataxia, and delayed development syndrome. Is an ortholog of several human genes including EBF1 (EBF transcription factor 1); EBF2 (EBF transcription factor 2); and EBF4 (EBF family member 4).
[Eddy SR] EcoRV RFLP correlated with unc-3. 3.8 kb EcoRV band in N2, 2.3 kb in unc-3 (mn419), 3.8 kb again in revertants unc-3 (mn419 mn422) and unc-3 (mn419 mn426), 3.7 kb in revertant unc-3 (mn419 mn431).