WormBase Tree Display for Expr_pattern: Expr9162
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| Expr9162 | Expression_of (2) | |
|---|---|---|
| Expression_data (3) | ||
| Subcellular_localization | ITX-1 defines a lateral membrane domain basal to the apical junction. However, ITX-1 staining along the apical junction appears as a wider belt differently than the typical AJM/DLG pattern. Moreover, ITX-1 localization is independent of AJM-1, as ajm-1 null mutant embryos show normal ITX-1 staining. Co-labeling of ITX-1 with anti beta-G Spectrin show that it co-localizes with ITX-1 along the entire lateral membrane of gut epithelia. | |
| Type | Antibody | |
| Pattern | Whole mount antibody staining established the expression of the protein at the baso-lateral membranes of gut epithelia in embryonic and post-embryonic stages. Its expression was restricted to gut and was not observed in other polarized epithelia, such as the pharynx or post-embryonic vulva, uterus, and hypodermis. Immunoelectron microscopy experiments confirmed localization of ITX-1 to intestinal adherens junctions. | |
| Picture | WBPicture0000012011 | |
| Remark | Picture: Fig. 5A to 5C. | |
| Reference | WBPaper00037763 | |
| Antibody_info | WBAntibody00002166 |
