WormBase Tree Display for Expr_pattern: Expr3159
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| Expr3159 | Expression_of | Gene | WBGene00003136 | |
|---|---|---|---|---|
| Reflects_endogenous_expression_of | WBGene00003136 | |||
| Expression_data | Anatomy_term | WBbt:0006797 | Certain | |
| Type | Northern | |||
| Pattern | The mau-2 mRNA levels were investigated in the germline by comparing wild-type young adults with adults carrying mutations that affect the germline. The mau-2 transcript level is extremely reduced in glp-4(bn2ts) mutants, which fail to develop a germline at 25C, indicating that most of the mau-2 mRNA in young adults is in the germline. Furthermore, the level of the mau-2 transcript is very high in fem-2(b245ts) mutants that make only oocytes at 25C, indicating that the oocytes are enriched with mau-2 transcript. However, the mau-2 transcript is very low in fem-3(q20ts) adults that make sperm only at 25C, indicating that the mau-2 transcript is not enriched in sperm. Taken together, these results indicate that oocytes accumulate high levels of mau-2 mRNA, presumably as a store to be used by the embryo. | |||
| Remark | Consistent with these observations, in situ hybridization data reported in the Nematode Expression Pattern Database for clone yk462a, which corresponds to mau-2, show an intense signal in the germline of adults, particularly in the pachytene region. In addition, a strong level of mau-2 mRNA is detected at different embryonic stages, including as early as the two-cell stage. | |||
| Reference | WBPaper00024594 |
