WormBase Tree Display for Expr_pattern: Expr10098
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| Expr10098 | Expression_of | Gene | WBGene00003812 |
|---|---|---|---|
| Reflects_endogenous_expression_of | WBGene00003812 | ||
| Expression_data (2) | |||
| Type | Reporter_gene | ||
| Pattern | Using transcriptional reporters, we found that the nrf-5 promoter (Pnrf-5) drove expression in body wall muscle cells. We also generated NRF-5 translational fusions with or without the secretion signal (Pnrf-5ssGFP::mNRF-5 and Pnrf-5GFP::mNRF-5). Secreted GFP::mNRF-5 (ssGFP::mNRF-5) displayed a diffuse staining pattern and associated with the basal surface of pharyngeal cells and the basal-lateral membranes of the intestine, whereas nonsecretory GFP::mNRF-5 labeled body wall muscle cells but not the intestine. These results suggest that NRF-5 is synthesized in and secreted from muscle cells to recognize apoptotic cells and associate with the basal surface of pharyngeal and intestine cells. | ||
| Picture | WBPicture0000012744 | ||
| WBPicture0000012745 | |||
| Reference | WBPaper00041220 | ||
| Transgene | WBTransgene00015228 | ||
| WBTransgene00015229 | |||
| WBTransgene00015230 |
