WormBase Tree Display for Disease_model_annotation: WBDOannot00001518
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| WBDOannot00001518 | Disease_term | DOID:10652 | |
|---|---|---|---|
| Disease_of_species | Homo sapiens | ||
| Modeled_by | Strain | WBStrain00056368 | |
| Association_type | is_model_of | ||
| Evidence_code | GO_code | IMP | |
| ECO_term | ECO:0007013 | ||
| Modifier_info | Modifier_gene | WBGene00001065 | |
| Modifier_association_type | condition_ameliorated_by | ||
| Genetic_sex | hermaphrodite | ||
| Paper_evidence | WBPaper00066033 | ||
| Disease_model_description | The C. elegans strain LSD2104 is a secreted form of human A-beta(1-42) tagged with GFP and is induced by heat shock; it is expressed in most tissues but predominantly in neurons and the hypodermis. This strain serves as a model for an inducible expression and secretion of human A-beta(1-42) tagged with super-folder GFP, in order to study neurodegeneration. This form of A-beta is retained and forms non-mobile structures in the extracellular matrix (ECM). RNAi knockdown of the cuticular collagen, dpy-3, resulted in the complete absence of both flower and moss patterned A-beta aggregates. | ||
| Curator_confirmed | WBPerson324 | ||
| Date_last_updated | 31 Mar 2024 00:00:00 |
