WormBase Tree Display for Analysis: Microarray_Study.WBPaper00045263.ce.mr
expand all nodes | collapse all nodes | view schema
| Microarray_Study.WBPaper00045263.ce.mr | DB_info | Database | GEO | GSE54024 |
|---|---|---|---|---|
| Title | Expression Data of Reactive Oxygen Species Signalling in C. elegans | |||
| Description | We have shown that worms that possess mutations in two electron transport chain subunits live longer due to mtROS signalling. Wild type worms can also live longer by treatment with the pro-oxidant paraquat. Paraquat treatment is not additive to the mutations in the ETC subunits. We aimed to determine the underlying changes in gene expression that were common to both paraquat treatment and the two mutations. We also have shown genetically that the mtROS signal that leads to extended lifespan is dependent on CED-4. We generated double mutants that lack functional CED-4 with the two mutations in the ETC subunits. We have found that a large number of gene expression changes by mtROS signalling are reverted by loss of CED-4. | |||
| Category | response to chemical | |||
| programmed cell death | ||||
| Microarray_experiment (22) | ||||
| Species_in_analysis | Caenorhabditis elegans | |||
| Reference | WBPaper00045263 |
