Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.
  • page settings
  • hide sidebar
  • show empty fields
  • layout
  • (too narrow)
  • open all
  • close all
Species » C. elegans(Genome assembly: WBcel235)

Expression cluster » WBPaper00066447:Day8_vs_Day1_upregulated_BodyWallMuscle

  • Clustered data

  • Genes

  • Tree Display

  • My Favorites

  • My Library

  • Comments on WBPaper00066447:Day8_vs_Day1_upregulated_BodyWallMuscle (0)

  • Overview

    WBPaper00066447:Day8_vs_Day1_upregulated_BodyWallMuscle

    Species:
    Caenorhabditis elegans
    WormBase ID:
    WBPaper00066447:Day8_vs_Day1_upregulated_BodyWallMuscle
    Micro RNAs that showed significantly increased expression in day 8 adults comparing to in day 1 adults in body wall muscle.

    Algorithm:

    Differentially expressed miRNAs were identified using DEGseq based on unique molecular identifier (UMI). A minimum UMI sum of 10 in 3 replicates was set as the threshold of expression. MiRNAs with more than five reads were defined as expressed. Differential expression of miRNAs was analysed by t-test (P value < 0.05 and fold-change > 1.5 or < 0.67) after Box-Cox transformation. MiRNA targets were identified by TargetScanWorm (Release 6.2) and Pearson Correlation Coefficient smaller than -0.2.

    Remarks:

  • References

    • Filter by article type
      • Journal article

      1

    1 reference found
    Tissue-specific profiling of age-dependent miRNAomic changes in Caenorhabditis elegans.
    Journal article
    Nat Commun
    2024

    Ageing exhibits common and distinct features in various tissues, making it critical to decipher the tissue-specific ageing mechanisms. MiRNAs are essential regulators in ageing and are recently highlighted as a class of intercellular messengers. However, little is known about the tissue-specific transcriptomic changes of miRNAs during ageing. C. elegans is a well-established model organism in ageing research. Here, we profile the age-dependent miRNAomic changes in five isolated worm tissues. Besides the diverse ageing-regulated miRNA expression across tissues, we discover numerous miRNAs in the tissues without their transcription. We further profile miRNAs in the extracellular vesicles and find that worm miRNAs undergo inter-tissue trafficking via these vesicles in an age-dependent manner. Using these datasets, we uncover the interaction between body wall muscle-derived mir-1 and DAF-16/FOXO in the intestine, suggesting mir-1 as a messenger in inter-tissue signalling. Taken together, we systematically investigate worm miRNAs in the somatic tissues and extracellular vesicles during ageing, providing a valuable resource to study tissue-autonomous and nonautonomous functions of miRNAs in ageing.

    Rows per page:
    ​
    1-1 of 1

  • Regulation

    No regulation data for WBPaper00066447:Day8_vs_Day1_upregulated_BodyWallMuscle
    Regulated by Gene:
    Regulated by Treatment:
    Regulated by Molecule:

  • Associations

    Anatomy Terms:
    Anatomy term Definition
    body wall muscle celltype of 95 cells that make up muscles of the body wall.
    Life Stages:
    Life Stages Definition
    1-day post-L4 adult hermaphrodite CeAt 20 Centigrade: 24-48 hours after L4-adult molt. 4-5 days after first cleavage.
    8-days post-L4 adult hermaphrodite CeAt 20 Centigrade: 8-9 days after L4-adult molt. 11-12 days after first cleavage.
    GO terms:
    Processes: