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Species » C. elegans(Genome assembly: WBcel235)

Expression cluster » WBPaper00065623:139

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  • Overview

    WBPaper00065623:139

    Species:
    Caenorhabditis elegans
    WormBase ID:
    WBPaper00065623:139
    Single-cell RNA-Seq cell group 139 expressed in: MI.

    Algorithm:

    CellRanger, DecontX, Monocle3, Louvain algorithm.

    Remarks:

  • Associations

    Anatomy Terms:
    Anatomy term Definition
    FLPNeuron class of two neurons, which have ciliated endings situated immediately dorsal to the lateral inner labial sensilla in the head but have no associated sheath or socket cells; they have flattened processes in this region of the cilium.
    MI neuronNeuron class of one pharyngeal motor neuron/interneuron.
    VB neuronNeuron class of eleven motoneurons, distributed along the ventral cord, which innervate ventral body muscles.
    I2 neuronNeuron class of two pharyngeal interneuron.
    LUANeuron class of two interneurons with cell bodies situated in the lumbar ganglia.
    SABNeuron class of three interneurons, which send processes anteriorly up the sub-lateral cords in the head.
    Life Stages:
    Life Stages Definition
    1-day post-L4 adult hermaphrodite CeAt 20 Centigrade: 24-48 hours after L4-adult molt. 4-5 days after first cleavage.
    GO terms:
    Processes:

  • Regulation

    No regulation data for WBPaper00065623:139
    Regulated by Gene:
    Regulated by Treatment:
    Regulated by Molecule:

  • References

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      • Journal article

      1

    1 reference found
    Whole-body gene expression atlas of an adult metazoan.
    Journal article
    Sci Adv
    2023

    Gene activity defines cell identity, drives intercellular communication, and underlies the functioning of multicellular organisms. We present the single-cell resolution atlas of gene activity of a fertile adult metazoan: <i>Caenorhabditis elegans</i>. This compendium comprises 180 distinct cell types and 19,657 expressed genes. We predict 7541 transcription factor expression profile associations likely responsible for defining cellular identity. We predict thousands of intercellular interactions across the <i>C. elegans</i> body and the ligand-receptor pairs that mediate them, some of which we experimentally validate. We identify 172 genes that show consistent expression across cell types, are involved in basic and essential functions, and are conserved across phyla; therefore, we present them as experimentally validated housekeeping genes. We developed the WormSeq application to explore these data. In addition to the integrated gene-to-systems biology, we present genome-scale single-cell resolution testable hypotheses that we anticipate will advance our understanding of the molecular mechanisms, underlying the functioning of a multicellular organism and the perturbations that lead to its malfunction.

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