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Species » C. elegans(Genome assembly: WBcel235)

Expression cluster » WBPaper00061508:S.aureus_12h_upregulated

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  • Comments on WBPaper00061508:S.aureus_12h_upregulated (0)

  • Overview

    WBPaper00061508:S.aureus_12h_upregulated

    Species:
    Caenorhabditis elegans
    WormBase ID:
    WBPaper00061508:S.aureus_12h_upregulated
    Proteins that showed significantly increased expression after 12 hours of exposure to S. aureus.

    Algorithm:

    N.A.

    Remarks:

    Type: Bacteria Infection

  • References

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      • Journal article

      1

    1 reference found
    Evaluation of changes in C. elegans immune response during bacterial infection: A single nematode approach.
    Journal article
    Microbes Infect
    2021

    Routinely, studies were performed using age-synchronized group of C. elegans as host which suggested a collective response by the host system. Here, we report the modulation of immune response in a single nematode against Staphylococcus aureus and Proteus mirabilis. Initially, the survival of wild-type N2 was tested and was found that S. aureus killed single nematode at 42 h while P. mirabilis failed to provoke infection but colonized the nematode's intestine. With this milieu, the pathogenicity of the bacteria was assessed by Fourier Transform Infra-Red (FTIR) spectroscopy and Cyclic Voltammetry (CV) and was found that S. aureus in the presence of host elicited its virulence while P. mirabilis and Escherichia coli OP50 did not show any alteration. Vertical transmission of infection was also deduced by colony forming unit assay using Cyanine dyes. The MALDI-TOF/TOF analysis was also performed to identify the proteome changes in the single nematode that showcased different proteins related to various immune pathways. This study suggested the importance of understanding the infection pathology and traits of individual nematode which could help our understanding on otherwise the disordered processes during host and microbe interactions.

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  • Associations

    No associations data for WBPaper00061508:S.aureus_12h_upregulated
    Anatomy Terms:
    Life Stages:
    GO terms:
    Processes:

  • Regulation

    Regulated by Gene:
    Regulated by Treatment:
    Bacteria infection: Staphylococcus aureus
    Regulated by Molecule: