Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.
  • page settings
  • hide sidebar
  • show empty fields
  • layout
  • (too narrow)
  • open all
  • close all
Species » C. elegans(Genome assembly: WBcel235)

Expression cluster » WBPaper00061203:sin-3(tm1276)_upregulated

  • Clustered data

  • Genes

  • Tree Display

  • My Favorites

  • My Library

  • Comments on WBPaper00061203:sin-3(tm1276)_upregulated (0)

  • Overview

    WBPaper00061203:sin-3(tm1276)_upregulated

    Species:
    Caenorhabditis elegans
    WormBase ID:
    WBPaper00061203:sin-3(tm1276)_upregulated
    Transcripts that showed significantly increased expression in sin-3(tm1276) comparing to in N2.

    Algorithm:

    DESeq2, fold change > 2, p-value < 0.01.

    Remarks:

  • Regulation

    Regulated by Gene:
    sin-3
    Regulated by Treatment:
    Regulated by Molecule:

  • Associations

    Anatomy Terms:
    Life Stages:
    Life Stages Definition
    1-day post-L4 adult hermaphrodite CeAt 20 Centigrade: 24-48 hours after L4-adult molt. 4-5 days after first cleavage.
    GO terms:
    Processes:

  • References

    • Filter by article type
      • Journal article

      1

    1 reference found
    Overlapping and non-overlapping roles of the class-I histone deacetylase-1 corepressors LET-418, SIN-3, and SPR-1 in Caenorhabditis elegans embryonic development.
    Journal article
    Genes Genomics
    2021

    BACKGROUND: Histone deacetylase (HDAC)-1, a Class-I HDAC family member, forms three types of complexes, the nucleosome remodeling deacetylase, Sin3, and CoREST complexes with the specific corepressor components chromodomain-helicase-DNA-binding protein 3 (Mi2/CHD-3), Sin3, and REST corepressor 1 (RCOR1), respectively, in humans. OBJECTIVE: To elucidate the functional relationships among the three transcriptional corepressors during embryogenesis. METHODS: The activities of HDA-1, LET-418, SIN-3, and SPR-1, the homologs of HDAC-1, Mi2, Sin3, and RCOR1 in Caenorhabditis elegans during embryogenesis were investigated through measurement of relative mRNA expression levels and embryonic lethality given either gene knockdown or deletion. Additionally, the terminal phenotypes of each knockdown and mutant embryo were observed using a differential-interference contrast microscope. Finally, the functional relationships among the three corepressors were examined through genetic interactions and transcriptome analyses. RESULTS: Here, we report that each of the corepressors LET-418, SIN-3, and SPR-1 are expressed and have essential roles in C. elegans embryonic development. Our terminal phenotype observations of single mutants further implied that LET-418, SIN-3, and SPR-1 play similar roles in promoting advancement to the middle and late embryonic stages. Combined analysis of genetic interactions and gene ontology of these corepressors indicate a prominent overlapping role among SIN-3, SPR-1, and LET-418 and between SIN-3 and SPR-1. CONCLUSION: Our findings suggest that the class-I HDAC-1 corepressors LET-418, SIN-3, and SPR-1 may cooperatively regulate the expression levels of some genes during C. elegans embryogenesis or may have some similar roles but functioning independently within a specific cell.

    Rows per page:
    ​
    1-1 of 1