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Species » C. elegans(Genome assembly: WBcel235)

Expression cluster » WBPaper00060434:pH4.33_vs_pH6.33_downrgulated

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  • Overview

    WBPaper00060434:pH4.33_vs_pH6.33_downrgulated

    Species:
    Caenorhabditis elegans
    WormBase ID:
    WBPaper00060434:pH4.33_vs_pH6.33_downrgulated
    Transcripts that showed significantly decreased expression after 3 hours of exposure to acidic environment (PH 4.33), comparing to control animals exposed to PH 6.33 environment.

    Algorithm:

    DESeq2 (1.16.1). The Benjamini and Hochberg's approach was used to adjust the resulting P-values to control the false discovery rate. Corrected value of P < 0.05 and fold change > 2 were set as the threshold for significantly differential expression.

    Remarks:

  • References

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      • Journal article

      1

    1 reference found
    Transcriptome Analysis of the Nematode <i>Caenorhabditis elegans</i> in Acidic Stress Environments.
    Journal article
    Front Physiol
    2020

    Ocean acidification and acid rain, caused by modern industries' fossil fuel burning, lead to a decrease in the living environmental pH, which results in a series of negative effects on many organisms. However, the underlying mechanisms of animals' response to acidic pH stress are largely unknown. In this study, we used the nematode <i>Caenorhabditis elegans</i> as an animal model to explore the regulatory mechanisms of organisms' response to pH decline. Two major stress-responsive pathways were found through transcriptome analysis in acidic stress environments. First, when the pH dropped from 6.33 to 4.33, the worms responded to the pH stress by upregulation of the <i>col</i>, <i>nas</i>, and <i>dpy</i> genes, which are required for cuticle synthesis and structure integrity. Second, when the pH continued to decrease from 4.33, the metabolism of xenobiotics by cytochrome P450 pathway genes (<i>cyp</i>, <i>gst</i>, <i>ugt</i>, and ABC transporters) played a major role in protecting the nematodes from the toxic substances probably produced by the more acidic environment. At the same time, the slowing down of cuticle synthesis might be due to its insufficient protective ability. Moreover, the systematic regulation pattern we found in nematodes might also be applied to other invertebrate and vertebrate animals to survive in the changing pH environments. Thus, our data might lay the foundation to identify the master gene(s) responding and adapting to acidic pH stress in further studies, and might also provide new solutions to improve assessment and monitoring of ecological restoration outcomes, or generate novel genotypes via genome editing for restoring in challenging environments especially in the context of acidic stress through global climate change.

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  • Regulation

    Regulated by Gene:
    Regulated by Treatment:
    Acidic Environment: PH 4.33 vs. PH 6.33.
    Regulated by Molecule:

  • Associations

    Anatomy Terms:
    Life Stages:
    Life Stages Definition
    L1 larva CeThe first stage larva. At 25 Centigrade, it ranges 14-25.5 hours after fertilization, 0-11.5 hours after hatch.
    GO terms:
    Processes: