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Species » C. elegans(Genome assembly: WBcel235)

Expression cluster » WBPaper00053140:SustainedResponse_20nmAgCit

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  • Overview

    WBPaper00053140:SustainedResponse_20nmAgCit

    Species:
    Caenorhabditis elegans
    WormBase ID:
    WBPaper00053140:SustainedResponse_20nmAgCit
    Transcripts that showed sustained response after C. elegans adults were exposed to 100 ug per mL 20nmAgCit in CeHM for 4, 8 or 24 h.

    Algorithm:

    Differentially expressed genes were selected using one-way analysis of variance (ANOVA) based on Welch t-test. To improve moderated t-statistics, the I/NI-calls gene filtering procedure was applied before the Welch t-test to exclude non-informative genes. For each comparison between two experimental groups, the fold change (FC) of every annotated gene, together with their corresponding p-value, was used for selection of differentially expressed genes with cutoffs of p < 0.05 and FC > 1.5.

    Remarks:

  • Regulation

    Regulated by Gene:
    Regulated by Treatment:
    Regulated by Molecule:
    Ag nanoparticles

  • Associations

    Anatomy Terms:
    Life Stages:
    Life Stages Definition
    adult CeThe stage that begins when a C.elegans individual is fully-developed and has reached maturity.
    GO terms:
    Processes:

  • References

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      • Journal article

      1

    1 reference found
    Bioactivity of nanosilver in Caenorhabditis elegans: Effects of size, coat, and shape.
    Journal article
    Toxicol Rep
    2014

    The in vivo toxicity to eukaryotes of nanosilver (AgNP) spheres and plates in two sizes each was assessed using the simple model organism Caenorhabditis elegans. For each shape, smaller AgNP size correlated with higher toxicity, as indicated by reduced larval growth. Smaller size also correlated with significant increases in silver uptake for silver nanospheres. Citrate coated silver spheres of 20 nm diameter induced an innate immune response that increased or held steady over 24 h, while regulation of genes involved in metal metabolism peaked at 4 h and subsequently decreased. For AgNP spheres, coating altered bioactivity, with a toxicity ranking of polyethylene glycol (PEG) &gt; polyvinylpyrrolidone (PVP) branched polyethyleneimine (BPEI) &gt; citrate, but silver uptake ranking of PEG &gt; PVP &gt; citrate &gt; BPEI. Our findings in C. elegans correlate well with findings in rodents for AgNP size vs. uptake and toxicity, as well as for induction of immune effectors, while using methods that are faster and far less expensive, supporting the use of C. elegans as an alternative model for early toxicity screening.

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