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Species » C. elegans(Genome assembly: WBcel235)

Expression cluster » WBPaper00045417:19Q-huntingtin_downreglated

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  • Overview

    WBPaper00045417:19Q-huntingtin_downreglated

    Species:
    Caenorhabditis elegans
    Attribute of Microarray experiment:
    WBPaper00045417:19Q_vs_GFP-only_rep1
    WBPaper00045417:19Q_vs_GFP-only_rep2
    WBPaper00045417:19Q_vs_GFP-only_rep3
    WormBase ID:
    WBPaper00045417:19Q-huntingtin_downreglated
    Genes that showed decreased expression in normal huntingtin (HTT) expressing 19Q touch receptor cells comparing to in GFP-only touch receptor cells.

    Algorithm:

    Authors performed the statistial analysis of the microarray data using the Varmixt tool of the R package, with VM parameters and FDR corrections of P-Values.

    Remarks:

    Regulated by human hungtintin gene (HTT)

  • References

    • Filter by article type
      • Journal article

      1

    1 reference found
    The Wnt receptor Ryk reduces neuronal and cell survival capacity by repressing FOXO activity during the early phases of mutant huntingtin pathogenicity.
    Journal article
    PLoS Biol
    2014

    The Wnt receptor Ryk is an evolutionary-conserved protein important during neuronal differentiation through several mechanisms, including -secretase cleavage and nuclear translocation of its intracellular domain (Ryk-ICD). Although the Wnt pathway may be neuroprotective, the role of Ryk in neurodegenerative disease remains unknown. We found that Ryk is up-regulated in neurons expressing mutant huntingtin (HTT) in several models of Huntington's disease (HD). Further investigation in Caenorhabditis elegans and mouse striatal cell models of HD provided a model in which the early-stage increase of Ryk promotes neuronal dysfunction by repressing the neuroprotective activity of the longevity-promoting factor FOXO through a noncanonical mechanism that implicates the Ryk-ICD fragment and its binding to the FOXO co-factor -catenin. The Ryk-ICD fragment suppressed neuroprotection by lin-18/Ryk loss-of-function in expanded-polyQ nematodes, repressed FOXO transcriptional activity, and abolished -catenin protection of mutant htt striatal cells against cell death vulnerability. Additionally, Ryk-ICD was increased in the nucleus of mutant htt cells, and reducing -secretase PS1 levels compensated for the cytotoxicity of full-length Ryk in these cells. These findings reveal that the Ryk-ICD pathway may impair FOXO protective activity in mutant polyglutamine neurons, suggesting that neurons are unable to efficiently maintain function and resist disease from the earliest phases of the pathogenic process in HD.

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  • Associations

    Anatomy Terms:
    Anatomy term Definition
    touch receptor neuronneurons that sense body touch, have specialized microtubules in processes.
    Life Stages:
    Life Stages Definition
    embryo CeThe whole period of embryogenesis in the nematode Caenorhabditis elegans, from the formation of an egg until hatching.
    GO terms:
    Processes:

  • Regulation

    No regulation data for WBPaper00045417:19Q-huntingtin_downreglated
    Regulated by Gene:
    Regulated by Treatment:
    Regulated by Molecule: