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Species » C. elegans(Genome assembly: WBcel235)

Expression cluster » WBPaper00045050:csr-1(hypomorph)_upregulated

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  • Comments on WBPaper00045050:csr-1(hypomorph)_upregulated (0)

  • Overview

    WBPaper00045050:csr-1(hypomorph)_upregulated

    Species:
    Caenorhabditis elegans
    WormBase ID:
    WBPaper00045050:csr-1(hypomorph)_upregulated
    Genes significantely Up-regulated by GRO-seq in csr-1 hypomorph vs. N2 using DESeq p < 0.05.

    Algorithm:

    DESeq package with an FDR of < 0.05.

    Remarks:

  • Associations

    Anatomy Terms:
    Life Stages:
    Life Stages Definition
    1-day post-L4 adult hermaphrodite CeAt 20 Centigrade: 24-48 hours after L4-adult molt. 4-5 days after first cleavage.
    L4 larva CeThe fourth stage larva. At 25 Centigrade, it ranges 40-49.5 hours after fertilization, 26-35.5 hours after hatch.
    GO terms:
    Processes:

  • References

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      • Journal article

      1

    1 reference found
    Global effects of the CSR-1 RNA interference pathway on the transcriptional landscape.
    Journal article
    Nat Struct Mol Biol
    2014

    Argonaute proteins and their small RNA cofactors short interfering RNAs are known to inhibit gene expression at the transcriptional and post-transcriptional levels. In Caenorhabditis elegans, the Argonaute CSR-1 binds thousands of endogenous siRNAs (endo-siRNAs) that are antisense to germline transcripts. However, its role in gene expression regulation remains controversial. Here we used genome-wide profiling of nascent RNA transcripts and found that the CSR-1 RNA interference pathway promoted sense-oriented RNA polymerase II transcription. Moreover, a loss of CSR-1 function resulted in global increase in antisense transcription and ectopic transcription of silent chromatin domains, which led to reduced chromatin incorporation of centromere-specific histone H3. On the basis of these findings, we propose that the CSR-1 pathway helps maintain the directionality of active transcription, thereby propagating the distinction between transcriptionally active and silent genomic regions.

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  • Regulation

    Regulated by Gene:
    csr-1
    Regulated by Treatment:
    Regulated by Molecule: