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Species » C. elegans(Genome assembly: WBcel235)

Expression cluster » WBPaper00026629:L2_male_enriched

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  • Overview

    WBPaper00026629:L2_male_enriched

    Species:
    Caenorhabditis elegans
    WormBase ID:
    WBPaper00026629:L2_male_enriched
    Genes eniched in hermaphrodites by comparing tra-2(ar221ts);xol-1(y9) XX phenotype males (at 25C) with either N2 or xol-1(y9) XX hermaphrodites during L2 larva stage

    Algorithm:

    Student t-test. An mRNA was considered to have sex-enriched expression if it showed at least a two-fold enrichment within a 99% confidence interval (P < 0.01).

    Remarks:

  • References

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      • Journal article

      1

    1 reference found
    Genome-wide analysis of sex-enriched gene expression during C. elegans larval development.
    Journal article
    Dev Biol
    2005

    Sex determination in C. elegans is controlled by the TRA-1 zinc finger protein, a Ci/GLI homolog that promotes female cell fates throughout the body. The regulatory hierarchy that controls TRA-1 is well established, but the downstream effectors that establish sexual dimorphism during larval development remain largely unknown. Here, we describe the use of cDNA microarrays to identify sex-enriched transcripts expressed during three stages of C. elegans larval development. By excluding previously identified germline-enriched transcripts, we focused on somatic sexual development. This approach identified a large number of sex-enriched transcripts that are good candidates to encode regulators of somatic sexual development. We found little overlap between genes with sex-enriched expression in early versus late larval development, indicating that distinct sexual regulatory programs operate at these times. Genes with sex-enriched expression are found throughout the genome, with no strong bias between autosomes and X chromosomes. Reporter gene analysis revealed that these genes are expressed in highly specific patterns in a variety of sexually dimorphic cells. We searched for TRA-1 consensus DNA binding sites near genes with sex-enriched expression, and found that most strongly sex-enriched mRNAs are likely to be regulated indirectly by TRA-1. These results suggest that TRA-1 controls sexual dimorphism through a small number of intermediary regulators rather than by acting directly on the full constellation of genes involved in sex-specific differentiation.

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  • Regulation

    No regulation data for WBPaper00026629:L2_male_enriched
    Regulated by Gene:
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    Regulated by Molecule:

  • Associations

    Anatomy Terms:
    Anatomy term Definition
    male-specific anatomical entitycells or anatomical parts specific to the male sex
    Life Stages:
    Life Stages Definition
    L2 larva CeThe second stage larva. At 25 Centigrade, it ranges 25.5-32.5 hours after fertilization, 11.5-18.5 hours after hatch.
    GO terms:
    Processes: