Seegobin SP [class:all]
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[species:All Species]
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- gene class: sptf
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[
Front Neurosci,
2020] Mutations in the leucine-rich repeat kinase 2 (<i>LRRK2</i>) gene are the most frequent cause of familial Parkinson's disease (PD). Several genetic manipulations of the <i>LRRK2</i> gene have been developed in animal models such as rodents, <i>Drosophila</i>, <i>Caenorhabditis elegans</i>, and zebrafish. These models can help us further understand the biological function and derive potential pathological mechanisms for LRRK2. Here we discuss common phenotypic themes found in <i>LRRK2</i>-associated PD animal models, highlight several issues that should be addressed in future models, and discuss emerging areas to guide their future development.
SP (Specificity Protein) Transcription Factor
[
J Helminthol,
2012] A survey of nematodes associated with native and introduced species of terrestrial slugs was conducted in the Western Cape Province of South Africa, in order to gather new data regarding diversity and distribution. A total of 521 terrestrial slugs were collected from 35 localities throughout the Western Cape. All slugs were dissected and examined for the presence of internal nematodes. Extracted nematodes were identified using a combination of molecular (18S rRNA gene sequencing) and morphological techniques. Nematodes were found parasitizing slugs at 14 of the 35 sites examined, amounting to 40% of sample sites. Of all slugs, 6% were infected with nematodes. A total of seven species of nematode were identified in the province, including Agfa flexilis, Angiostoma sp., Phasmarhabditis sp. SA1, Phasmarhabditis sp. SA2, Caenorhabditis elegans, Panagrolaimus sp. and Rhabditis sp. Of these species, four were thought to be parasitic to slugs (A. flexilis, Angiostoma sp., Phasmarhabditis sp. SA1 and Phasmarhabditis sp. SA2), as opposed to forming necromenic or phoretic associations. Three new species of slug-parasitic nematode were identified during this study (Angiostoma sp., Phasmarhabditis sp. SA1 and Phasmarhabditis sp. SA2).
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