paper:

Krab IM et al. (2002) Prog Nucleic Acid Res Mol Biol "Mechanisms of EF-Tu, a pioneer GTPase."

Krab IM, Parmeggiani A

[Prog Nucleic Acid Res Mol Biol, 2002]

This review considers several aspects of the function of EF-Tu, a protein that has greatly contributed to the advancement of our knowledge of both protein biosynthesis and GTP-binding proteins in general. A number of topics are described with emphasis on the function-structure relationships, in particular of EF-Tu's domains, the nucleotide-binding site, and the magnesium-binding network. Aspects related to the interaction with macromolecular ligands and antibiotics and to folding and GTPase activity are also presented and discussed. Comments and criticism are offered to draw attention to remaining discrepancies and problems.

go term: pancreatic A cell fate commitment

The commitment of a cell to a pancreatic A cell and its capacity to differentiate into a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon.

go term: phosphatidylethanolamine-sterol O-acyltransferase activity

Catalysis of the reaction: a phosphatidylethanolamine + a sterol = a sterol ester + a lysophosphatidylethanolamine.

go term: phosphatidate-sterol O-acyltransferase activity

Catalysis of the reaction: a phosphatidate + a sterol = a sterol ester + a lysophosphatidate.

go term: D-2-hydroxyacid dehydrogenase (quinone) activity

Catalysis of the reaction: a (2R)-2-hydroxycarboxylate + a quinone = a 2-oxocarboxylate + a quinol.

disease ontology: acute eustachian salpingitis [DOID:10550]

A otosalpingitis with a sudden onset and a short course.

anatomy term: SM lineage cell

A cell that is a sex myoblast or is a lineal descendant of a sex myoblast.

go term: protein serine/threonine phosphatase complex

A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein.

go term: protein localization to mast cell secretory granule

A process in which a protein is transported to, or maintained in, a location within a secretory granule in a mast cell.

go term: nucleoside phosphotransferase activity

Catalysis of the reaction: a nucleotide + a 2'-deoxynucleoside = a nucleoside + a 2'-deoxynucleoside 5'-monophosphate.