Modric T [class:all]
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[species:All Species]
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20K results (0.015 seconds)
- paper:
- go term: pyrimidine dimer repair
- gene class: tnt
- go term: thymine/thymine mispair binding
- gene class: cit
- disease ontology: primary cutaneous T-cell non-Hodgkin lymphoma [DOID:0060061]
- go term: photoreactive repair
- go term: aclacinomycin T methylesterase activity
- gene class: rnst
[
Toxicol Appl Pharmacol,
1994] The random, free-radical-mediated oxidations of biological molecules result in membrane degradation leading to cellular deterioration (B. Halliwell, Free Radical Res. Commun. 9, 1-32, 1990). External oxygen, prooxidants, and internally produced oxygen free radicals (oxyradicals), interact and alter the nature of biomembranes. Antioxidants, e.g., tocopherol (Vitamin E), inhibit such oxidative damage of free radicals. In the present study, the nematode Caenorhabditis elegans was grown under hyperoxia (100% oxygen) with or without the addition of Vitamin E to the growth media. The nematodes were viable under such conditions for at least eight generations, although fecundity gradually decreased through successive generations, presumably due to genetic load. Vitamin E was also shown to have a protective effect against paraquat, which is a strong, intracellular, oxidizing agent. Ultrastructural observations of early meiosis showed that the formation of synaptonemal complexes was compromised and that the telomeres failed to attach to the nuclear envelope. Those nematodes grown in 100% oxygen with 200 micrograms/ml Vitamin E had normal meiotic structures and normal fecundity. Thus, the presence of enhanced levels of intracellular Vitamin E resulted in protection against oxidative stress during gametogenesis.
The repair of UV-induced T-T, C-T and C-C dimers.
TropoNin T
Binding to a double-stranded DNA region containing a T/T mispair.
CyclIn T
A peripheral T-cell lymphoma that has_material_basis_in a mutation of T cells.
The repair of UV-induced T-T, C-T and C-C dimers by directly reversing the damage to restore the original pyrimidines.
Catalysis of the reaction: aclacinomycin T(1+) + H2O = 15-demethylaclacinomycin T + methanol + H+.
RiboNucleaSe T homolog
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