Heffernan, Nathan [class:all]
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3 results (0.007 seconds)
- person: Nathan Heffernan Duke University; Durham NC, United States of America
- paper:
[
International Worm Meeting,
2021] High sugar diets are cited as a causal factor in the ongoing increase in obesity rates as Americans consume over 75 g of refined sugar and corn syrup per day on average. Further, obesity is associated with increased risk for multiple negative health outcomes including the neurodegenerative disease Parkinson's Disease. Utilizing C. elegans to investigate the effects of two common dietary sugars, glucose and fructose, we investigated the systemic and dopaminergic neuron-specific effects of high sugar diets on bioenergetics and susceptibility to mitochondrial dysfunction. Through the use of in vivo fluorescent reporters and Seahorse XF whole worm respiratory analysis, we found that glucose-fed worms exhibited a 14.9% increase in basal oxygen consumption and alterations to dopaminergic neuronal mitochondrial dynamics and morphology. Our study also indicated that unlike exposures beginning during development, chronic adult high glucose and high fructose diets are protective from 6-hydroxydopamine-induced dopaminergic neurodegeneration, despite deleterious impacts on lifespan and reproduction. These findings support the idea that a shift to glycolytic metabolism protects from acute electron transport chain inhibition, while also supporting previously observed adverse impacts of high sugar diets.
