Chen, Kevin [class:all]
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213 results (0.01 seconds)
- person: Kevin Chen Massachusetts General Hospital; Charlestown MA, United States of America
- person: Kevin Chen Rutgers, The State University of New Jersey; Piscataway NJ, United States of America
- person: Kevin Chen Princeton University; Princeton NJ, United States of America
- person: Kevin Chen Washington University School of Medicine; St. Louis MO, United States of America
- paper:
- person: Kevin S Chen Princeton University; Princeton NJ, United States of America
[
International Worm Meeting,
2015] Model organisms have played a critical role in our understanding of innate immunity. The recent discovery of Orsay virus, the 1st virus capable of infecting C. elegans, and the discoveries of Santeuil and Le Blanc viruses which infect C. briggsae, provide a unique opportunity to define virus host interactions in these model hosts. In order to identify candidate antiviral genes, we have performed a time course transcriptional profiling with RNA-seq. In C. elegans, we identified 151 genes that were differentially expressed upon Orsay virus infection. In this set, only 36 have annotation; 22 genes contain domains involved in ubiquitin-mediated proteolysis. By further defining the transcriptional response of the orthologous genes in C. briggsae to Santeuil and Le Blanc virus infection, we identified 39 conserved genes induced in both hosts by the three viruses. Strikingly, 17 of the 39 conserved response genes are paralogs of a single gene family that is exemplified by C17H1.3. This gene family has a human ortholog, but no known function has been associated to these orthologous genes. The conserved induction of these genes in response to infection by multiple viruses strongly suggests they may play a role in antiviral defense. Efforts to define such function by targeted gene deletion and overexpression are underway. .
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