Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.
  • page settings
  • hide sidebar
  • show empty fields
  • layout
  • (too narrow)
  • open all
  • close all
Resources » Paper

Zhang H et al. (2024) Cell "The extracellular matrix integrates mitochondrial homeostasis."

  • History

  • Referenced

  • Tree Display

  • My Favorites

  • My Library

  • Comments on Zhang H et al. (2024) Cell "The extracellular matrix integrates mitochondrial homeostasis." (0)

  • Overview

    PMID:
    38942015
    DOI:
    10.1016/j.cell.2024.05.057
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00067307

    Zhang H, Tsui CK, Garcia G, Joe LK, Wu H, Maruichi A, Fan W, Pandovski S, Yoon PH, Webster BM, Durieux J, Frankino PA, Higuchi-Sanabria R, & Dillin A (2024). The extracellular matrix integrates mitochondrial homeostasis. Cell, 187, 4289-4304.e26. doi:10.1016/j.cell.2024.05.057

    Cellular homeostasis is intricately influenced by stimuli from the microenvironment, including signaling molecules, metabolites, and pathogens. Functioning as a signaling hub within the cell, mitochondria integrate information from various intracellular compartments to regulate cellular signaling and metabolism. Multiple studies have shown that mitochondria may respond to various extracellular signaling events. However, it is less clear how changes in the extracellular matrix (ECM) can impact mitochondrial homeostasis to regulate animal physiology. We find that ECM remodeling alters mitochondrial homeostasis in an evolutionarily conserved manner. Mechanistically, ECM remodeling triggers a TGF-&#x3b2; response to induce mitochondrial fission and the unfolded protein response of the mitochondria (UPR<sup>MT</sup>). At the organismal level, ECM remodeling promotes defense of animals against pathogens through enhanced mitochondrial stress responses. We postulate that this ECM-mitochondria crosstalk represents an ancient immune pathway, which detects infection- or mechanical-stress-induced ECM damage, thereby initiating adaptive mitochondria-based immune and metabolic responses.

    Authors: Zhang H, Tsui CK, Garcia G, Joe LK, Wu H, Maruichi A, Fan W, Pandovski S, Yoon PH, Webster BM, Durieux J, Frankino PA, Higuchi-Sanabria R, Dillin A


    Tip: Seeing your name marked red? Please help us identify you.