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Resources » Paper

Zhao Y et al. (2023) J Agric Food Chem "Novel Genes and Key Signaling Molecules Involved in the Repulsive Response of Meloidogyne incognita against Biocontrol Bacteria."

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  • Comments on Zhao Y et al. (2023) J Agric Food Chem "Novel Genes and Key Signaling Molecules Involved in the Repulsive Response of Meloidogyne incognita against Biocontrol Bacteria." (0)

  • Overview

    PMID:
    38033160
    DOI:
    10.1021/acs.jafc.3c06074
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00066430

    Zhao Y, Zhong C, Li Y, Zhou W, & Huang X (2023). Novel Genes and Key Signaling Molecules Involved in the Repulsive Response of Meloidogyne incognita against Biocontrol Bacteria. J Agric Food Chem. doi:10.1021/acs.jafc.3c06074

    The ability of the model organism, <i>Caenorhabditis elegans</i>, to distinguish and escape from pathogenic bacteria has been extensively studied; however, studies on the repulsive response of <i>Meloidogyne incognita</i> are still in their infancy. We have recently demonstrated that biocontrol bacteria induce a repulsive response in <i>M. incognita</i> via two classical signaling pathways. The present study aimed to identify the novel genes and signaling molecules of <i>M. incognita</i> that potentially contribute to its defense reaction. Analysis of the transcriptome data of <i>M. incognita</i> with and without a repulsive response against <i>Bacillus nematocida</i> B16 obtained 15 candidate genes, of which the novel genes <i>Minc3s01748g26034</i> and <i>Minc3s02548g30585</i> were found to regulate the aversive behavior of <i>M. incognita</i>, and their functions were further validated. To further confirm the neuronal localization of the two novel genes in <i>M. incognita</i>, in situ hybridization was conducted using the digoxin-labeled probes of ten tag genes, and preferentially profiled the localization of amphid sensory neurons of <i>M. incognita</i>. Analysis of the overviewed neuronal map suggested that <i>Minc3s01748g26034</i> and <i>Minc3s02548g30585</i> functioned in ASK/ASI and CEPD/V neurons, respectively. During their interactions, the volatile compounds 3-methyl-butyric acid and 2-methyl-butyric acid produced by the biocontrol bacteria were predicted as the primary signaling molecules that promoted the repulsive behavior of <i>M. incognita</i> against biocontrol bacteria. The findings provided novel insights into the mechanisms underlying the repulsive response of <i>M. incognita</i> that are different from the canonical molecular pathways previously found in <i>C. elegans</i> and can aid in developing novel strategies for controlling root-knot nematodes.

    We thank Xiaowei Huang for curating this paper through ACKnowledge (Author Curation to Knowledgebase) 👍

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