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Resources » Paper

Jose A et al. (2024) MicroPubl Biol "NALCN Channels Are Not Major targets of Gα o or Gα q Modulation in the C. elegans Egg-Laying Behavior Circuit."

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  • Comments on Jose A et al. (2024) MicroPubl Biol "NALCN Channels Are Not Major targets of Gα o or Gα q Modulation in the C. elegans Egg-Laying Behavior Circuit." (0)

  • Overview

    PMID:
    38287929
    DOI:
    10.17912/micropub.biology.001065
    Status:
    Publication type:
    Journal_article, Micropublication
    WormBase ID:
    WBPaper00066271

    Jose A, & Collins K (2024). NALCN Channels Are Not Major targets of Gα o or Gα q Modulation in the C. elegans Egg-Laying Behavior Circuit. MicroPubl Biol, 2024. doi:10.17912/micropub.biology.001065

    Sodium leak channels (NALCN) are regulators of cell membrane potential. Previous studies in mammalian neurons and <i>C. elegans</i> have shown that G&#x3b1; <sub>q</sub> and G&#x3b1; <sub>o</sub> signaling antagonistically modulates NALCN activity to regulate neuron excitability and neurotransmitter release for behavior. Here, we test whether NALCNs mediate the effects of G&#x3b1; <sub>q</sub> and/or G&#x3b1; <sub>o</sub> signaling in the <i>C. elegans</i> egg-laying circuit. We find that while gain-of-function NALCN mutants exhibit hyperactive egg-laying behavior, NALCNs are not required for the effects of G&#x3b1; <sub>q</sub> or G&#x3b1; <sub>o</sub> signaling for egg laying. These results show that NALCNs are not major effectors of G-protein signaling for <i>C. elegans</i> egg-laying behavior.


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