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Resources » Paper

Chen C et al. (2023) Molecules "High-Dose Deltamethrin Induces Developmental Toxicity in Caenorhabditis elegans via IRE-1."

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  • Comments on Chen C et al. (2023) Molecules "High-Dose Deltamethrin Induces Developmental Toxicity in Caenorhabditis elegans via IRE-1." (0)

  • Overview

    PMID:
    37687132
    DOI:
    10.3390/molecules28176303
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00066178

    Chen C, Deng Y, Liu L, Zou Z, Jin C, Chen Z, & Wang S (2023). High-Dose Deltamethrin Induces Developmental Toxicity in Caenorhabditis elegans via IRE-1. Molecules, 28. doi:10.3390/molecules28176303

    Deltamethrin (DM), a Type II pyrethroid, is widely used worldwide in agriculture, household applications, and medicine. Recent studies have shown that DM exerts a variety of toxic effects on organs such as the kidney, heart muscle, and nerves in animals. However, little is known about the effects of high-dose DM on growth and development, and the mechanism of toxicity remains unclear. Using the <i>Caenorhabditis elegans</i> model, we found that high-dose DM caused a delay in nematode development. Our results showed that high-dose DM reduced the activation of the endoplasmic reticulum unfolded protein response (UPR<sup>ER</sup>). Further studies revealed that high-dose DM-induced developmental toxicity and reduced capacity for UPR<sup>ER</sup> activation were associated with the IRE-1/XBP-1 pathway. Our results provide new evidence for the developmental toxicity of DM and new insights into the mechanism of DM toxicity.


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