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Resources » Paper

Meng X et al. (2023) J Cell Biol "Triggered Golgi membrane enrichment promotes PtdIns(4,5)P2 generation for plasma membrane repair."

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  • Comments on Meng X et al. (2023) J Cell Biol "Triggered Golgi membrane enrichment promotes PtdIns(4,5)P2 generation for plasma membrane repair." (0)

  • Overview

    PMID:
    37158801
    DOI:
    10.1083/jcb.202303017
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00065357

    Meng X, Wijaya CS, Shao Q, & Xu S (2023). Triggered Golgi membrane enrichment promotes PtdIns(4,5)P2 generation for plasma membrane repair. J Cell Biol, 222. doi:10.1083/jcb.202303017

    The maintenance of plasma membrane integrity and a capacity for efficiently repairing damaged membranes are essential for cell survival. Large-scale wounding depletes various membrane components at the wound sites, including phosphatidylinositols, yet little is known about how phosphatidylinositols are generated after depletion. Here, working with our in vivo C. elegans epidermal cell wounding model, we discovered phosphatidylinositol 4-phosphate (PtdIns4P) accumulation and local phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] generation at the wound site. We found that PtdIns(4,5)P2 generation depends on the delivery of PtdIns4P, PI4K, and PI4P 5-kinase PPK-1. In addition, we show that wounding triggers enrichment of the Golgi membrane to the wound site, and that is required for membrane repair. Moreover, genetic and pharmacological inhibitor experiments support that the Golgi membrane provides the PtdIns4P for PtdIns(4,5)P2 generation at the wounds. Our findings demonstrate how the Golgi apparatus facilitates membrane repair in response to wounding and offers a valuable perspective on cellular survival mechanisms upon mechanical stress in a physiological context.

    We thank Suhong Xu for curating this paper through ACKnowledge (Author Curation to Knowledgebase) 👍

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