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Resources » Paper

Godoy LF et al. (2023) Transcription "Transcriptional and spatiotemporal regulation of the dauer program."

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  • Comments on Godoy LF et al. (2023) Transcription "Transcriptional and spatiotemporal regulation of the dauer program." (0)

  • Overview

    PMID:
    36951297
    DOI:
    10.1080/21541264.2023.2190295
    Status:
    Publication type:
    Review
    WormBase ID:
    WBPaper00065151

    Godoy LF, & Hochbaum D (2023). Transcriptional and spatiotemporal regulation of the dauer program. Transcription, 1-22. doi:10.1080/21541264.2023.2190295

    Caenorhabditis elegans can enter a diapause stage called "dauer" when it senses that the environment is not suitable for development. This implies a detour from the typical developmental trajectory and requires a tight control of the developmental clock and a massive tissue remodeling. In the last decades, core components of the signaling pathways that govern the dauer development decision have been identified, but the tissues where they function for the acquisition of dauer-specific traits are still under intense study. Growing evidence demonstrates that these pathways engage in complex cross-talk and feedback loops. In this review, we summarize the current knowledge regarding the transcriptional regulation of the dauer program and the relevant tissues for its achievement. A better understanding of this process will provide insight on how developmental plasticity is achieved and how development decisions are under a robust regulation to ensure an all-or-nothing response. Furthermore, this developmental decision can also serve as a simplified model for relevant developmental disorders.Abbreviations: AID Auxin Induced Degron DA dafachronic acid Daf-c dauer formation constitutive Daf-d dauer formation defective DTC Distal Tip Cells ECM modified extracellular matrix GPCRs G protein-coupled receptors IIS insulin/IGF-1 signaling ILPs insulin-like peptides LBD Ligand Binding Domain PDL4 Post Dauer L4 TGF-β transforming growth factor beta WT wild-type.


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