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Resources » Paper

Liu X et al. (2022) Chemosphere "Ecotoxicity induced by total, water soluble and insoluble components of atmospheric fine particulate matter exposure in Caenorhabditis elegans."

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  • Comments on Liu X et al. (2022) Chemosphere "Ecotoxicity induced by total, water soluble and insoluble components of atmospheric fine particulate matter exposure in Caenorhabditis elegans." (0)

  • Overview

    PMID:
    36587918
    DOI:
    10.1016/j.chemosphere.2022.137672
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00064811

    Liu X, Ge P, Lu Z, Cao M, Chen W, Yan Z, Chen M, & Wang J (2022). Ecotoxicity induced by total, water soluble and insoluble components of atmospheric fine particulate matter exposure in Caenorhabditis elegans. Chemosphere, 137672. doi:10.1016/j.chemosphere.2022.137672

    Although PM<sub>2.5</sub> could cause toxicity in environmental organisms, the toxicity difference of PM<sub>2.5</sub> under different solubilities is still poorly understood. To acquire a better knowledge of the ecotoxicity of PM<sub>2.5</sub> under different solubilities, the model animal Caenorhabditis elegans (C. elegans) was exposed to Total-PM<sub>2.5</sub>, water insoluble components of PM<sub>2.5</sub> (WIS-PM<sub>2.5</sub>) and water soluble components of PM<sub>2.5</sub> (WS-PM<sub>2.5</sub>). The physiological (growth, locomotion behavior, and reproduction), biochemical (germline apoptosis, and reactive oxygen species (ROS) production) indices, and the related gene expression were examined. According to the findings, acute exposure to these three components caused adverse physiological effects on growth and locomotion behavior, and significantly induced germline apoptosis or ROS production. In contrast, prolonged exposure showed stronger adverse effects than acute exposure. Additionally, the results of multiple toxicological endpoints showed that the toxicity effects of WIS-PM<sub>2.5</sub> are more intense than WS-PM<sub>2.5</sub>, which means that insoluble components contributed more to the toxicity of PM<sub>2.5</sub>. Prolonged exposure to 1000&#x202f;mg/L WS-PM<sub>2.5</sub>, WIS-PM<sub>2.5</sub>, and Total-PM<sub>2.5</sub> dramatically altered the expression of stress-related genes, which further indicated that apoptosis, DNA damage and oxidative stress play a crucial part in toxicity induced by PM<sub>2.5</sub>.

    Authors: Liu X, Ge P, Lu Z, Cao M, Chen W, Yan Z, Chen M, Wang J


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