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Resources » Paper

Arata, Yukinobu et al. (2021) International Worm Meeting "Insulin signaling underlies a heavy-tailed temporal organization in C. elegans episodic swimming"

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  • Overview

    Status:
    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00063572

    Arata, Yukinobu, Shiga, Itsuki, Ikeda, Yusaku, Kimura, Hiroshi, Jurica, Peter, Kiyono, Ken, & Sako, Yasushi (2021). Insulin signaling underlies a heavy-tailed temporal organization in C. elegans episodic swimming presented in International Worm Meeting. Unpublished information; cite only with author permission.

    Episodic bouts of animal behaviors are not periodic, but temporally organized in a scale-free manner with long memory in many animal species including human. It is known that depression in human is associated with defects in the scale-free temporal organization of behaviors and impacts on social fitness, and accordingly exacerbates disease state. C. elegans crawls in on agar plate and swim in a solution while switching between actively-moving state and inactive state, which is referred to as episodic behavior. We have shown that the residence time in each state in episodic swimming has a scale-free or heavy-tailed property with long memory. Here, we studied how the residence times between two states are cross-correlated by using detrending moving-average cross-correlation analysis (DMCA) to activity time series obtained from a long-term culture of C. elegans. We found that residence times in the active and inactive states are correlated with each other over the time scale from minutes to hours, or at the ultradian time scale. This temporal cross-correlation disappeared when cultured in M9 buffer without food bacteria, and restored when cultured M9 buffer only with glucose. Additionally, the temporal cross-correlation disappeared in the mutant animals of daf-2 gene, which encodes the membrane receptor for insulin growth factor signal and in the mutant of daf-16, which encodes a downstream transcriptional repressor FOXO. Therefore, we conclude that the temporal cross-correlation is achieved by the insulin signaling. Glucose metabolism disorders and behavioral disorders are known to be closely related in human depression, raising the possibility that the temporal organization by insulin signaling found in C. elegans is conserved in humans.

    Affiliations:
    - Department of Mechanical Engineering, Tokai University, Hiratsuka, Kanagawa
    - Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka
    - Cellular Informatics Laboratory, RIKEN, Wako, Saitama


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