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Comments on Kim, Seung Hyun et al. (2021) International Worm Meeting "Two RapGaps in C. elegans differently regulate development and behavior." (0)
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Kim, Seung Hyun, Lee, Sun-Kyung, & Ahnn, Joohong (2021). Two RapGaps in C. elegans differently regulate development and behavior presented in International Worm Meeting. Unpublished information; cite only with author permission.
RAP GTPase is a Ras-like small GTPase family known to regulate cell adhesion and cell to cell junction. RAP GTPase is activated when bound to GTP and deactivated when GDP is attached to the protein. RAP Guanine nucleotide Exchange Factor (RAPGEF) can detach the bound GDP to let free GTP bind to the RAP and be activated. RAP GTPase Activating Protein (RAPGAP) promotes hydrolysis of bound GTP to inactivate the RAP signal. In human cells, RAP signaling activated by RAPGAP can promote cancer invasion and metastasis. Knockout of RAPGEF arrests the cell junction at zipper state and stops it from cell junction maturation. In C. elegans, RAP GTPase and its upstream regulator PXF-1, C. elegans ortholog of human RAPGEF2, regulate VPC primary cell fate reinforcement, cuticle formation, hypodermal cell organization, and male ray formation. This study aims to find the role and the target protein of two C. elegans RAPGAPs, rgap-1 and rgap-2. rgap-1 deletion mutant exhibits higher autophagy level and shorter lifespan than N2. Also, rgap-1 deletion mutant is more sensitive to serotonin and levamisole mediated egg-laying and has a larger brood size. On the other hand, rgap-2 seems to be in a different pathway in organismal development and longevity. With further study, we will investigate the expression pattern and the functional role of rgap-2, and investigate genetic interaction between those two RAPGAPs.
Affiliations:
- Department of Life Science, College of Natural Sciences, Hanyang University
- Research Institute for Natural Sciences, College of Natural Sciences, Hanyang University