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Resources » Paper

Faerberg, Denis et al. (2021) International Worm Meeting "Discerning the temporal organization of development"

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    Status:
    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00063250

    Faerberg, Denis, Gurarie, Victor, & Ruvinsky, Ilya (2021). Discerning the temporal organization of development presented in International Worm Meeting. Unpublished information; cite only with author permission.

    Understanding temporal regulation of development remains an important challenge. Whereas average, species-typical timing of many developmental processes has been established, less is known about inter-individual variability and correlations in timing of specific events. We are studying these questions in the context of development in Caenorhabditis elegans. In one study, based on patterns of locomotor activity of freely moving animals, we inferred durations of four larval stages (L1-L4) in over 100 individuals. Analysis of these data supports several conclusions. Individuals have consistently faster or slower rates of development because durations of L1 through L3 stages are positively correlated. The last larval stage, the L4, is less variable than the earlier stages and its duration is largely independent of the rate of early larval development, implying existence of two distinct larval epochs. Interestingly, stage durations tend to scale relative to total developmental time. Fractional stage durations (calculated as L1 duration/total time to adulthood, etc.) are indistinguishable across several independent studies that relied on different methodologies and were conducted at different temperatures. This scaling relationship suggests that each larval stage is not limited by an absolute duration, but is instead terminated when a subset of events that must occur prior to adulthood have been completed. Comparing these results to our more recent studies of developmental timing allows the inference of general principles of temporal organization of development.

    Affiliations:
    - University of Colorado
    - Northwestern University


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