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Resources » Paper

Palani, Sankara et al. (2021) International Worm Meeting "Regulation of temperature-induced longevity response by neuronal GPCR NPR-8 in Caenorhabditis elegans"

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  • Comments on Palani, Sankara et al. (2021) International Worm Meeting "Regulation of temperature-induced longevity response by neuronal GPCR NPR-8 in Caenorhabditis elegans" (0)

  • Overview

    Status:
    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00062776

    Palani, Sankara, Sellegounder, Durai, & Liu, Yiyong (2021). Regulation of temperature-induced longevity response by neuronal GPCR NPR-8 in Caenorhabditis elegans presented in International Worm Meeting. Unpublished information; cite only with author permission.

    Various studies in both poikilotherms and homeotherms have associated lower temperature with longer lifespan and higher temperature with shorter lifespan. These inverse effects of temperature on longevity were traditionally explained by the "rate of living theory", which posits that higher temperatures increase chemical reaction rates, thus speeding up the aging process. Recent studies have identified specific molecules and cells that mediate the longevity response to temperature, suggesting that the temperature effects on aging are not simply thermodynamic but regulated processes. The mechanisms underlying such regulation, however, are not well understood. In the current study, we found that Caenorhabditis elegans lacking NPR-8, a neuronal GPCR related to mammalian neuropeptide Y receptors, exhibited extended lifespan at warm temperature. Further investigation uncovered an NPR-8-longevity regulatory circuit that includes the thermosensory neurons AFD and the amphid sensory neurons AWB, AWC, and probably ASJ. Transcriptomic analyses revealed that NPR-8 controls collagen gene expression in the longevity response to temperature. Functions of the NPR-8-regulated collagen genes in this process are currently under investigation. These results suggest the temperature effects on longevity are regulated by the nervous system possibly via controlling collagen gene expression. Our study potentially provides mechanistic insights into understanding the relationship between temperature and longevity in humans, which could prove useful in mitigating negative impacts of increasing temperature due to global warming in a world with an aging population.

    Affiliation:
    - Department of Biomedical Sciences, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA


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