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Resources » Paper

Kim, BanSeok et al. (2021) International Worm Meeting "Spaceflight effects on muscle size in C. elegans"

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    Status:
    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00062736

    Kim, BanSeok, Alcantara, Alfredo Jr., Moon, Je-Hyun, Lee, JinIl, & Higashitani, Atsushi (2021). Spaceflight effects on muscle size in C. elegans presented in International Worm Meeting. Unpublished information; cite only with author permission.

    Many countries are planning on space colonization, researching space habitation and even privatizing space travel. However, if we travel to space in the future, our bodies will be exposed to space environment during long-term space flight. Previous studies have revealed that space microgravity induces muscle atrophy. To understand how microgravity affects muscle and motor neuron that traverses body wall muscle, we focused on the GABAergic motor neurons in C. elegans, the DD/VD neurons. We sent C. elegans to the ISS in space to find any changes in DD/VD neurons and muscles. The worms who were born in microgravity environment were frozen after six days from birth and parental worms who experienced both 1G and microgravity condition were frozen together, and we received these samples. While we were analyzing the neurons as well as muscle size and shape by immunostaining, we were faced with a difficulty seeing GFP of DD/VD neurons because of their weak signal. Thus, we could check only muscle size of C. elegans using phalloidin staining method. Preliminary results show that space microgravity-exposed worms aboard the ISS may show differences in size compared to ground-control samples. We are currently analyzing muscle size in other space samples, as well as DD/VD motor neuron development. Keywords : space flight, microgravity, muscle size

    Affiliations:
    - Division of Biological Science and Technology, College of Science and Technology, Yonsei University, Wonju, South Korea
    - Graduate School of Life Sciences, Tohoku University, Sendai, Japan


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