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Resources » Paper

Sengupta T et al. (2021) Elife "Differential adhesion regulates neurite placement via a retrograde zippering mechanism."

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  • Comments on Sengupta T et al. (2021) Elife "Differential adhesion regulates neurite placement via a retrograde zippering mechanism." (0)

  • Overview

    PMID:
    34783657
    DOI:
    10.7554/eLife.71171
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00062128

    SenGupta T, Koonce NL, Vazquez-MartInez N, Moyle MW, Duncan LH, Emerson SE, Han X, Shao L, Wu Y, Santella A, Fan L, Bao Z, Mohler W, Shroff H, & Colon-Ramos DA (2021). Differential adhesion regulates neurite placement via a retrograde zippering mechanism. Elife, 10. doi:10.7554/eLife.71171

    During development, neurites and synapses segregate into specific neighborhoods or layers within nerve bundles. The developmental programs guiding placement of neurites in specific layers, and hence their incorporation into specific circuits, are not well understood. We implement novel imaging methods and quantitative models to document the embryonic development of the <i>C. elegans</i> brain neuropil<i>,</i> and discover that differential adhesion mechanisms control precise placement of single neurites onto specific layers. Differential adhesion is orchestrated via developmentally-regulated expression of the IgCAM SYG-1, and its partner ligand SYG-2. Changes in SYG-1 expression across neuropil layers result in changes in adhesive forces, which sort SYG-2-expressing neurons. Sorting to layers occurs, not via outgrowth from the neurite tip, but via an alternate mechanism of retrograde zippering, involving interactions between neurite shafts. Our study indicates that biophysical principles from differential adhesion govern neurite placement and synaptic specificity <i>in vivo</i> in developing neuropil bundles.

    Authors: SenGupta T, Koonce NL, Vazquez-MartInez N, Moyle MW, Duncan LH, Emerson SE, Han X, Shao L, Wu Y, Santella A, Fan L, Bao Z, Mohler W, Shroff H, Colon-Ramos DA

    We thank Daniel Colon-Ramos for curating this paper through ACKnowledge (Author Curation to Knowledgebase) 👍

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