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Resources » Paper

Gal C et al. (2021) Cell Rep "DREAM represses distinct targets by cooperating with different THAP domain proteins."

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  • Comments on Gal C et al. (2021) Cell Rep "DREAM represses distinct targets by cooperating with different THAP domain proteins." (0)

  • Overview

    PMID:
    34686342
    DOI:
    10.1016/j.celrep.2021.109835
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00062056

    Gal C, Carelli FN, Appert A, Cerrato C, Huang N, Dong Y, Murphy J, Frapporti A, & Ahringer J (2021). DREAM represses distinct targets by cooperating with different THAP domain proteins. Cell Rep, 37, 109835. doi:10.1016/j.celrep.2021.109835

    The DREAM (dimerization partner [DP], retinoblastoma [Rb]-like, E2F, and MuvB) complex controls cellular quiescence by repressing cell-cycle and other genes, but its mechanism of action is unclear. Here, we demonstrate that two C.elegans THAP domain proteins, LIN-15B and LIN-36, co-localize with DREAM and function by different mechanisms for repression of distinct sets of targets. LIN-36 represses classical cell-cycle targets by promoting DREAM binding and gene body enrichment of H2A.Z, and we find that DREAM subunit EFL-1/E2F is specific for LIN-36 targets. In contrast, LIN-15B represses germline-specific targets in the soma by facilitating H3K9me2 promoter marking. We further find that LIN-36 and LIN-15B differently regulate DREAM binding. In humans, THAP proteins have been implicated in cell-cycle regulation by poorly understood mechanisms. We propose that THAP domain proteins are key mediators of Rb/DREAM function.

    Authors: Gal C, Carelli FN, Appert A, Cerrato C, Huang N, Dong Y, Murphy J, Frapporti A, Ahringer J


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