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Resources » Paper

Dysarz J et al. (2021) Biol Lett "Genes implicated in Caenorhabditis elegans and human health regulate stress resistance and physical abilities in aged Caenorhabditis elegans."

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  • Comments on Dysarz J et al. (2021) Biol Lett "Genes implicated in Caenorhabditis elegans and human health regulate stress resistance and physical abilities in aged Caenorhabditis elegans." (0)

  • Overview

    PMID:
    34102068
    DOI:
    10.1098/rsbl.2020.0916
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00061476

    Dysarz J, Fuellen G, Moller S, Luyten W, Schmitz-Linneweber C, & Saul N (2021). Genes implicated in Caenorhabditis elegans and human health regulate stress resistance and physical abilities in aged Caenorhabditis elegans. Biol Lett, 17, 20200916. doi:10.1098/rsbl.2020.0916

    Recently, nine <i>Caenorhabditis elegans</i> genes, grouped into two pathways/clusters, were found to be implicated in healthspan in <i>C. elegans</i> and their homologues in humans, based on literature curation, WormBase data mining and bioinformatics analyses. Here, we further validated these genes experimentally in <i>C. elegans</i>. We downregulated the nine genes via RNA interference (RNAi), and their effects on physical function (locomotion in a swim assay) and on physiological function (survival after heat stress) were analysed in aged nematodes. Swim performance was negatively affected by the downregulation of <i>acox-1.1</i>, <i>pept-1</i>, <i>pak-2</i>, <i>gsk-3</i> and <i>C25G6.3</i> in worms with advanced age (twelfth day of adulthood) and heat stress resistance was decreased by RNAi targeting of <i>acox-1.1</i>, <i>daf-22</i>, <i>cat-4</i>, <i>pig-1</i>, <i>pak-2</i>, <i>gsk-3</i> and <i>C25G6.3</i> in moderately (seventh day of adulthood) or advanced aged nematodes. Only one gene, <i>sad-1</i>, could not be linked to a health-related function in <i>C. elegans</i> with the bioassays we selected. Thus, most of the healthspan genes could be re-confirmed by health measurements in old worms.

    We thank Nadine Saul for curating this paper through ACKnowledge (Author Curation to Knowledgebase) 👍

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