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Resources » Paper

Yasuda K et al. (2021) Biochem Biophys Rep "Cortisol promotes stress tolerance via DAF-16 in Caenorhabditis elegans."

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  • Comments on Yasuda K et al. (2021) Biochem Biophys Rep "Cortisol promotes stress tolerance via DAF-16 in Caenorhabditis elegans." (0)

  • Overview

    PMID:
    33732902
    DOI:
    10.1016/j.bbrep.2021.100961
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00061242

    Yasuda K, Kubo Y, Murata H, & Sakamoto K (2021). Cortisol promotes stress tolerance via DAF-16 in Caenorhabditis elegans. Biochem Biophys Rep, 26, 100961. doi:10.1016/j.bbrep.2021.100961

    In this study, we studied the effects of cortisol and cortisone on the age-related decrease in locomotion in the nematode <i>Caenorhabditis elegans</i> and on the tolerance to heat stress at 35C and to oxidative stress induced by the exposure to 0.1% H<sub>2</sub>O<sub>2</sub>. Changes in mRNA expression levels of <i>C. elegans</i> genes related to stress tolerance were also analyzed. Cortisol treatment restored nematode movement following heat stress and increased viability under oxidative stress, but also shortened worm lifespan. Cortisone, a cortisol precursor, also restored movement after heat stress. Additionally, cortisol treatment increased mRNA expression of the <i>hsp-12.6</i> and <i>sod-3</i> genes. Furthermore, cortisol treatment failed to restore movement of <i>daf-16</i>-deficient mutants after heat stress, whereas cortisone failed to restore the movement of <i>dhs-30</i>-deficient mutants after heat stress. In conclusion, the results suggested that cortisol promoted stress tolerance via DAF-16 but shortened the lifespan, whereas cortisone promoted stress tolerance via DHS-30.


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