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Resources » Paper

Liu H et al. (2020) Environ Res "Multigenerational effects of polyethylene terephthalate microfibers in Caenorhabditis elegans."

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  • Comments on Liu H et al. (2020) Environ Res "Multigenerational effects of polyethylene terephthalate microfibers in Caenorhabditis elegans." (0)

  • Overview

    PMID:
    33275924
    DOI:
    10.1016/j.envres.2020.110569
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00060695

    Liu H, Kwak JI, Wang D, & An YJ (2020). Multigenerational effects of polyethylene terephthalate microfibers in Caenorhabditis elegans. Environ Res, 110569. doi:10.1016/j.envres.2020.110569

    Microfibers (MFs) have recently become an increasingly prevalent pollutant in ecosystems and pose a direct threat to organisms and an indirect threat via adsorption of other pollutants. Here, we used Caenorhabditis elegans to study multigenerational effects of polyethylene terephthalate (PET) MFs (diameter 17.4 m) by observing the maternal generation (P0) to the seventh offspring generation (F7) with continuous MF exposure. Exposure to 250-m PET MFs decreased locomotion behavior and induced intestinal reactive oxygen species (ROS) in the P0 generation compared with other PET MF sizes. Moreover, no notably negative effects on survival were observed in any generation during continuous exposure to 250-m PET MFs. However, the reproduction rate clearly decreased in the F2 and F3 generations but gradually recovered in the F4F7 generations. Developmental abnormalities showed a close relationship with body length. Although some recovery was confirmed, there were significant decreases in body length in the F2F5 generations. Interestingly, growth inhibition was also observed in the F6 generation without MF exposure. ROS production and dermal damage in the P0F5 generations might have resulted in the toxicological responses. To the best of our knowledge, this is the first study to provide evidence of multigenerational toxicity of MFs in C. elegans.


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