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Resources » Paper

Barriere A et al. (2020) J Neurogenet "Neuronal specification in C. elegans: combining lineage inheritance with intercellular signaling."

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  • Comments on Barriere A et al. (2020) J Neurogenet "Neuronal specification in C. elegans: combining lineage inheritance with intercellular signaling." (0)

  • Overview

    PMID:
    32603241
    DOI:
    10.1080/01677063.2020.1781850
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00060289

    Barriere A, & Bertrand V (2020). Neuronal specification in C. elegans: combining lineage inheritance with intercellular signaling. J Neurogenet, 1-9. doi:10.1080/01677063.2020.1781850

    The nervous system is composed of a high diversity of neuronal types. How this diversity is generated during development is a key question in neurobiology. Addressing this question is one of the reasons that led Sydney Brenner to develop the nematode <i>C. elegans</i> as a model organism. While there was initially a debate on whether the neuronal specification follows a 'European' model (determined by ancestry) or an 'American' model (determined by intercellular communication), several decades of research have established that the truth lies somewhere in between. Neurons are specified by the combination of transcription factors inherited from the ancestor cells and signaling between neighboring cells (especially Wnt and Notch signaling). This converges to the activation in newly generated postmitotic neurons of a specific set of terminal selector transcription factors that initiate and maintain the differentiation of the neuron. In this review, we also discuss the evolution of these specification mechanisms in other nematodes and beyond.


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