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Resources » Paper

Hao S et al. (2020) J Agric Food Chem "Hydroxycinnamic acid from Corncob and Its Structural Analogues Inhibit A40 Fibrillation and Attenuate A40-Induced Cytotoxicity."

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  • Comments on Hao S et al. (2020) J Agric Food Chem "Hydroxycinnamic acid from Corncob and Its Structural Analogues Inhibit A40 Fibrillation and Attenuate A40-Induced Cytotoxicity." (0)

  • Overview

    PMID:
    32700906
    DOI:
    10.1021/acs.jafc.0c01841
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00060023

    Hao S, Li X, Han A, Yang Y, Luo X, Fang G, Wang H, Liu J, & Wang S (2020). Hydroxycinnamic acid from Corncob and Its Structural Analogues Inhibit A40 Fibrillation and Attenuate A40-Induced Cytotoxicity. J Agric Food Chem. doi:10.1021/acs.jafc.0c01841

    The aggregation of amyloid- protein (A) is deemed a vital pathological feature of Alzheimer's disease (AD). Hence, inhibiting A aggregation is noticed as a major tactic for the prevention and therapy of AD. Hydroxycinnamic acid, as a natural phenolic compound is widely present in plant foods and has several biological activities including anti-inflammation, antioxidation and neuroprotective effects. Here it was found that hydroxycinnamic acid and its structural analogues (3-hydroxycinnamic acid, 2-hydroxycinnamic acid, cinnamic acid, 3,4-dihydroxycinnamic acid, 2,4-dihydroxycinnamic acid and 3,4,5-trihydroxycinnamic acid) could inhibit A40 fibrillogenesis and reduce A40-induced cytotoxicity in a dose-dependent manner. Among these small molecules investigated, 3,4,5-trihydroxycinnamic acid is considered to be the most effective inhibitor, which reduces ThT uorescence intensity to 30.79% and increases cell viability from 49.47% to 84.78% at 200 M. And the results with C. elegans tested that these small molecules can ameliorate AD-like symptoms of worm paralysis. Moreover, molecular docking studies showed that these small molecules interact with the A40 mainly via hydrogen-bonding. These results suggest that hydroxycinnamic acid and its structural analogues could inhibit A40 fibrillogenesis and the inhibition activity is enhanced with the increase of phenolic hydroxyl groups of inhibitors. These small molecules have huge potential to be developed into a novel aggregation inhibitor in neurodegenerative disorders.

    Authors: Hao S, Li X, Han A, Yang Y, Luo X, Fang G, Wang H, Liu J, Wang S


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