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Resources » Paper

Hsu HW et al. (2020) Development "C. elegans flamingo FMI-1 controls dendrite self-avoidance through F-actin assembly."

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  • Comments on Hsu HW et al. (2020) Development "C. elegans flamingo FMI-1 controls dendrite self-avoidance through F-actin assembly." (0)

  • Overview

    PMID:
    32631831
    DOI:
    10.1242/dev.179168
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00059953

    Hsu HW, Liao CP, Chiang YC, Syu RT, & Pan CL (2020). C. elegans flamingo FMI-1 controls dendrite self-avoidance through F-actin assembly. Development. doi:10.1242/dev.179168

    Self-avoidance is a conserved mechanism that prevents crossover between sister dendrites from the same neuron, ensuring proper functioning of the neuronal circuits. Several adhesion molecules are known to be important for dendrite self-avoidance, but the underlying molecular mechanisms are incompletely defined. Here we show that FMI-1/Flamingo, an atypical cadherin, is required autonomously for self-avoidance in the multidendritic PVD neuron of <i>C. elegans</i> The <i>fmi-1</i> mutant shows increased crossover between sister PVD dendrites. Our genetic analysis suggests that FMI-1 promotes transient F-actin assembly at the tips of contacting sister dendrites to facilitate their efficient retraction during self-avoidance events, likely by interacting with WSP-1/N-WASP. Mutations of <i>vang-1</i>, which encodes the planar cell polarity protein Vangl2 previously shown to inhibit F-actin assembly, suppress self-avoidance defects of the <i>fmi-1</i> mutant. FMI-1 downregulates VANG-1 level likely through forming protein complexes. Our study identifies molecular links between Flamingo and the F-actin cytoskeleton for efficient dendrite self-avoidance.

    We thank Chun-Liang Pan for curating this paper through ACKnowledge (Author Curation to Knowledgebase) 👍

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