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Resources » Paper

Takagaki N et al. (2020) EMBO Rep "The mechanoreceptor DEG-1 regulates cold tolerance in Caenorhabditis elegans."

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  • Comments on Takagaki N et al. (2020) EMBO Rep "The mechanoreceptor DEG-1 regulates cold tolerance in Caenorhabditis elegans." (0)

  • Overview

    PMID:
    32009302
    DOI:
    10.15252/embr.201948671
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00059258

    Takagaki N, Ohta A, Ohnishi K, Kawanabe A, Minakuchi Y, Toyoda A, Fujiwara Y, & Kuhara A (2020). The mechanoreceptor DEG-1 regulates cold tolerance in Caenorhabditis elegans. EMBO Rep, e48671. doi:10.15252/embr.201948671

    Caenorhabditis elegans mechanoreceptors located in ASG sensory neurons have been found to sense ambient temperature, which is a key trait for animal survival. Here, we show that experimental loss of xanthine dehydrogenase (XDH-1) function in AIN and AVJ interneurons results in reduced cold tolerance and atypical neuronal response to changes in temperature. These interneurons connect with upstream neurons such as the mechanoreceptor-expressing ASG. Ca<sup>2+</sup> imaging revealed that ASG neurons respond to warm temperature via the mechanoreceptor DEG-1, a degenerin/epithelial Na<sup>+</sup> channel (DEG/ENaC), which in turn affects downstream AIN and AVJ circuits. Ectopic expression of DEG-1 in the ASE gustatory neuron results in the acquisition of warm sensitivity, while electrophysiological analysis revealed that DEG-1 and human MDEG1 were involved in warm sensation. Taken together, these results suggest that cold tolerance is regulated by mechanoreceptor-mediated circuit calculation.

    Authors: Takagaki N, Ohta A, Ohnishi K, Kawanabe A, Minakuchi Y, Toyoda A, Fujiwara Y, Kuhara A

    We thank Atsushi Kuhara for curating this paper through ACKnowledge (Author Curation to Knowledgebase) 👍

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