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Resources » Paper

Cao X et al. (2019) J Agric Food Chem "Photolysis induced neurotoxicity enhancement of Chlorpyrifos in aquatic system: a case investigation on Caenorhabditis elegans."

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  • Comments on Cao X et al. (2019) J Agric Food Chem "Photolysis induced neurotoxicity enhancement of Chlorpyrifos in aquatic system: a case investigation on Caenorhabditis elegans." (0)

  • Overview

    PMID:
    31868356
    DOI:
    10.1021/acs.jafc.9b05908
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00059009

    Cao X, Yan C, Yang X, Zhou L, Zou W, & Xiu G (2019). Photolysis induced neurotoxicity enhancement of Chlorpyrifos in aquatic system: a case investigation on Caenorhabditis elegans. J Agric Food Chem. doi:10.1021/acs.jafc.9b05908

    Contamination of the environment by toxic pesticides has become of great concern in agricultural countries. Chlorpyrifos (CP) is among the pesticides most commonly detected in the environment owing to its wide agricultural applications. The aim of this study was to compare potential changes in the toxicity of CP after irradiation. To this end, photolysis of CP was conducted under simulated sunlight, and neurotoxicity assessment was carried out at CP of 20 and 50 g L-1 and its corresponding irradiated mixture solutions which contain a mixture of identified intermediates using the nematode, Caenorhabditis elegans as a model organism. Photodegradation of 20 g L-1 CP for 1 h produced no obvious reduction of physiological damage, and more serious effects on animal movement were detected after exposure of the animals to a solution of 50 g L-1 for 1 h compared with unirradiated solution. GABAergic and cholinergic neurons were selectively vulnerable to CP exposure, and maximal neuropathological alterations were observed after 1 h irradiation of the CP solutions in coherence with the behavioural impairment. The generation of photoproducts was considered to be responsible for the enhanced disturbance on those biological process. This work provided useful information on the toxicological assessments of chemicals that were produced during the environmental transformation of pesticides.


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