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Resources » Paper

Yu G et al. (2019) Int J Mol Sci "The Epigenetics of Aging in Invertebrates."

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  • Overview

    PMID:
    31540238
    DOI:
    10.3390/ijms20184535
    Status:
    Publication type:
    Review
    WormBase ID:
    WBPaper00058614

    Yu G, Wu Q, Gao Y, Chen M, & Yang M (2019). The Epigenetics of Aging in Invertebrates. Int J Mol Sci, 20. doi:10.3390/ijms20184535

    Aging is an unstoppable process coupled to the loss of physiological function and increased susceptibility to diseases. Epigenetic alteration is one of the hallmarks of aging, which involves changes in DNA methylation patterns, post-translational modification of histones, chromatin remodeling and non-coding RNA interference. Invertebrate model organisms, such as <i>Drosophila melanogaster</i> and <i>Caenorhabditis elegans</i>, have been used to investigate the biological mechanisms of aging because they show, evolutionarily, the conservation of many aspects of aging. In this review, we focus on recent advances in the epigenetic changes of aging with invertebrate models, providing insight into the relationship between epigenetic dynamics and aging.


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