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Comments on Kim J et al. (2019) Nutrients "Worm-Based Alternate Assessment of Probiotic Intervention against Gut Barrier Infection." (0)
Overview
Kim J, & Moon Y (2019). Worm-Based Alternate Assessment of Probiotic Intervention against Gut Barrier Infection. Nutrients, 11. doi:10.3390/nu11092146
The epithelial barrier is the frontline defense against enteropathogenic bacteria and nutrition-linked xenobiotic stressors in the alimentary tract. In particular, enteropathogenic <i>Escherichia coli</i> (EPEC) insults the gut barrier and is increasingly implicated in chronic intestinal diseases such as inflammatory bowel disease. For the efficient development of intervention against barrier-linked distress, the present study provided a <i>Caenorhabditis elegans</i>-based assessment instead of extensive preclinical evaluations using mammalian models. In particular, EPEC infected the gut and shortened the lifespan of <i>C. elegans</i>, which was counteracted by colonization of <i>E. coli</i> strain Nissle 1917 (EcN). In addition to the competitive actions of EcN against EPEC, EcN improved the gut barrier integrity of worms via the Zonula occludens ortholog (Zoo-1) induction, which was verified in the murine infection and colitis model. The worm-based assessment provided a crucial methodology and important insights into the potent chronic events in the human gut barrier after the ingestion of probiotic candidates as a mucoactive dietary or therapeutic agent.
