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Resources » Paper

Hanna, M. et al. (2019) International Worm Meeting "Identifying Genetic Targets of the Transcription Factor FKH-8 in C. elegans ."

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  • Comments on Hanna, M. et al. (2019) International Worm Meeting "Identifying Genetic Targets of the Transcription Factor FKH-8 in C. elegans ." (0)

  • Overview

    Status:
    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00058398

    Hanna, M., Roach, C., Quinde, J., & Nelms, B. (2019). Identifying Genetic Targets of the Transcription Factor FKH-8 in C. elegans presented in International Worm Meeting. Unpublished information; cite only with author permission.

    Dopamine (DA) is an important neurotransmitter. DA neurons are involved in both motor and cognitive functions, and disruption of DA signaling is associated with multiple diseases and disorders, such as Parkinson's disease, depression, addiction, and ADHD. A better understanding of the molecules that control DA neuron fate and function can help us target and genetically treat these diseases. The transcription factor FKH-8 regulates the expression of other genes and is enriched in DA neurons from embryonic development and continued through adulthood. Loss of FKH-8 results in a DA-dependent movement defect - swimming induced paralysis (SWIP). Cell-specific RNA sequencing has the power to identify all genes that are expressed in a cell and has identified 534 genes abundantly enriched in DA neurons. Using RT-qPCR to validate these data, we are quantifying and comparing the expression of target genes in the presence (wildtype) versus absence (knock out) of FKH-8 in whole-worms and in DA neurons. From these data, we will further characterize FKH-8's role in regulating downstream targets.

    Affiliation:
    - Biology, Fisk University, Nashville, TN


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