Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.
  • page settings
  • hide sidebar
  • show empty fields
  • layout
  • (too narrow)
  • open all
  • close all
Resources » Paper

Moreira, P. et al. (2019) International Worm Meeting "Decoding the role of the NFY transcription factor in brain development."

  • History

  • Referenced

  • Tree Display

  • My Favorites

  • My Library

  • Comments on Moreira, P. et al. (2019) International Worm Meeting "Decoding the role of the NFY transcription factor in brain development." (0)

  • Overview

    Status:
    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00058340

    Moreira, P., Deng, J., Cornell, R., & Pocock, R. (2019). Decoding the role of the NFY transcription factor in brain development presented in International Worm Meeting. Unpublished information; cite only with author permission.

    The establishment of correct brain architecture during development is an exceptionally complex process requiring precisely controlled cell specification, migration, axon outgrowth and guidance. These events are controlled by multiple transcription factors, conserved guidance systems and environmental cues. The Caenorhabditis elegans nervous system is an excellent model to study brain development due to its relative simplicity and conserved nature of development. My PhD project aims to identify molecular mechanisms that drive brain development. Using an unbiased genetic screen, we identified a Nuclear Factor Y transcriptional complex (NFY) that controls the development of a pair of glutamatergic interneurons. The NFY family is one of the most abundant and conserved transcription factors in eukaryotes and is involved in the regulation genes associated with several developmental steps. The NFY trimeric complex comprises the conserved NFY-A, -B and -C subunits that regulate gene expression through binding specific motifs in promoter regions. Our preliminary data show that the NFY complex regulates neuronal fate and axon guidance of specific neurons. Using single-cell resolution analysis, transcriptomics and ChIP sequencing I will decipher the molecular mechanism(s) through which NFYs control neuronal development.

    Affiliation:
    - Biomedicine Discovery Institute, Department of Anatomy and Development Biology, Monash University, Melbourne, VIC.


    Tip: Seeing your name marked red? Please help us identify you.