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Resources » Paper

Raizen, D.M. et al. (2019) International Worm Meeting "Sleep enhances survival during viral infection."

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    Status:
    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00058309

    Raizen, D.M., Um, Paul, Grubbs, Jeremy, van der Linden, Alexander, & Iannacone, Michael (2019). Sleep enhances survival during viral infection presented in International Worm Meeting. Unpublished information; cite only with author permission.

    While it is widely appreciated that infection is associated with sleepiness and fatigue, the underlying mechanisms of infection-induced sleep and the benefit of this sleep has remained largely a mystery. Here, we used the Orsay virus model to explore these questions in C. elegans. The Orsay virus infects the intestinal cells yet has strong effects on behavior, indicating interactions between somatic and neural cells. Locomotion and feeding quiescence were increased in infected animals. Infection-induced sleep, like sleep in response to other stressors such UV light, required the neuropeptide processing enzyme EGL-21 as well as the ALA neuron. Surprisingly, our preliminary data suggests that the somnogenic neuron RIS, which is required for sleep in response to other stressors, was not required for virus-induced quiescence. Worms that lacked the ALA neuron (i.e. failed to sleep in response to infection), showed a 30% reduction in median lifespan compared to infected control animals. This survival benefit of sleep could not be explained by a difference in the viral load of sleeping vs. sleepless animals, nor could it be explained by differences in the transcriptional intracellular pathogen response. Sleepless infected animals had lower ATP levels than sleeping infected animals, suggesting that sleep benefits the animal at the level of energetics. This model presents an opportunity to understand the mechanism of sleepiness during infections and the protective role of sleep in host-pathogen interactions.

    Affiliations:
    - Department of Biology, University of Nevada
    - Department of Neurology, University of Pennsylvania Perelman School of Medicine


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