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Comments on Ayuda-Duran B et al. (2019) Foods "Antioxidant Characterization and Biological Effects of Grape Pomace Extracts Supplementation in Caenorhabditis elegans." (0)
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Ayuda-Duran B, Gonzalez-Manzano S, Gil-Sanchez I, Moreno-Arribas MV, Bartolome B, Sanz-Buenhombre M, Guadarrama A, Santos-Buelga C, & Gonzalez-Paramas AM (2019). Antioxidant Characterization and Biological Effects of Grape Pomace Extracts Supplementation in Caenorhabditis elegans. Foods, 8. doi:10.3390/foods8020075
The aim of this work was to evaluate the biological activity of four grape pomace (GP) extracts that are rich in polyphenols using <i>C. elegans</i> as an in vivo model. Different concentrations of the GP extracts were assessed for their effects on the resistance of <i>C. elegans</i> against thermally induced oxidative stress, accumulation of reactive oxygen species (ROS), and lifespan. The cultivation of <i>C. elegans</i> with relatively low concentrations of GP extracts increased their resistance against thermal stress and prolonged their lifespan, while high levels displayed detrimental effects. In the studied extracts, maximum protection was observed for levels of polyphenols around 7 to 9 g gallic acid equivalents per cultivation plate. The obtained results suggested that small changes in the ROS levels could have beneficial effects, although further studies are required to fully understand the impact of the extracts and assayed doses on ROS levels to explain the mechanism that is involved in the observed effects.
Authors: Ayuda-Duran B, Gonzalez-Manzano S, Gil-Sanchez I, Moreno-Arribas MV, Bartolome B, Sanz-Buenhombre M, Guadarrama A, Santos-Buelga C, Gonzalez-Paramas AM
